OMPdecaseOrotidine 5'-phosphate decarboxylase / HUMPS family |
---|
SMART accession number: | SM00934 |
---|---|
Description: | Orotidine 5'-phosphate decarboxylase (OMPdecase) (PUBMED:2835631), (PUBMED:1730672) catalyzes the last step in the de novo biosynthesis of pyrimidines, the decarboxylation of OMP into UMP. In higher eukaryotes OMPdecase is part, with orotate phosphoribosyltransferase, of a bifunctional enzyme, while the prokaryotic and fungal OMPdecases are monofunctional protein. |
Interpro abstract (IPR001754): | Orotidine 5'-phosphate decarboxylase (OMPdecase) [ (PUBMED:2835631) (PUBMED:1730672) ] catalyses the last step in the de novo biosynthesis of pyrimidines, the decarboxylation of OMP into UMP. In higher eukaryotes OMPdecase is part, with orotate phosphoribosyltransferase, of a bifunctional enzyme, while the prokaryotic and fungal OMPdecases are monofunctional protein. Some parts of the sequence of OMPdecase are well conserved across species. The best conserved region is located in the N-terminal half of OMPdecases and is centred around a lysine residue which is essential for the catalytic function of the enzyme. This entry also includes enzymes such as 3-hexulose-6-phosphate synthase EC 4.1.2.43 and 3-keto-L-gulonate-6-phosphate decarboxylase EC 4.1.1.85 . |
GO process: | 'de novo' pyrimidine nucleobase biosynthetic process (GO:0006207) |
GO function: | orotidine-5'-phosphate decarboxylase activity (GO:0004590) |
Family alignment: |
There are 26255 OMPdecase domains in 26251 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
-
Taxonomic distribution of proteins containing OMPdecase domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with OMPdecase domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing OMPdecase domain in the selected taxonomic class.
- Cellular role (predicted cellular role)
-
Cellular role: metabolism
- Literature (relevant references for this domain)
-
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Kimsey HH, Kaiser D
- The orotidine-5'-monophosphate decarboxylase gene of Myxococcus xanthus.Comparison to the OMP decarboxylase gene family.
- J Biol Chem. 1992; 267: 819-24
- Display abstract
The nucleotide sequence of the Myxococcus xanthusorotidine-5'-monophosphate decarboxylase (OMP DCase) gene was determined.The derived protein sequence is not closely related to other prokaryoticOMP DCase sequences; nor is it closely related to any eukaryotic OMP DCasesequences. Progressive multiple alignment of the M. xanthus OMP DCaseprotein sequence with 19 other OMP DCase sequences revealed four conservedregions present in all 20 sequences. Ten entirely conserved residues werefound in these four regions and one region contains a tight cluster of 5conserved residues, certain of which may be catalytically active residues.A second open reading frame was found upstream of uraA and oriented in thesame direction as uraA. A stretch of 21 consecutive pyrimidine (C or T)residues were found in the intercistronic region between the potentialribosome-binding site of uraA and the UGA stop codon of the upstream openreading frame. RNA directly upstream of the pyrimidine run, including theUGA stop codon of the upstream open reading frame, could be folded into astable hairpin structure resembling Rho-independent terminators ofEscherichia coli. Expression of the uraA gene may be regulated by anintercistronic transcription termination mechanism.
- Jacquet M, Guilbaud R, Garreau H
- Sequence analysis of the DdPYR5-6 gene coding for UMP synthase inDictyostelium discoideum and comparison with orotate phosphoribosyltransferases and OMP decarboxylases.
- Mol Gen Genet. 1988; 211: 441-5
- Display abstract
A Dictyostelium discoideum DNA fragment that complements the ura3 and theura5 mutants of Saccharomyces cerevisiae has been sequenced. It containsan open reading frame of 478 codons capable of encoding a polypeptide ofmolecular weight 52475. This gene, named DdPYR5-6, encodes a bifunctionalprotein composed of the orotate phosphoribosyl transferase (OPRTase) andthe orotidine-5'-phosphate decarboxylase (OMPdecase) domains described forUMP synthase in mammals. The existence of separate domains for the twoactivities was suspected because deletion of the N-terminal coding segmentof the gene eliminated the ura5 but not the ura3 complementing activity.We have now confirmed that the two parts of the open reading frame sharehomology with known OPRTase and OMPdecase sequences. Several blocks ofsequence are conserved among OPRTase from bacteria, fungi and slime moldand one of them corresponds to the consensus sequence forphosphoribosylbinding sites. The OMPdecase domain shows extensivesimilarity with the yeast and Neurospora crassa enzymes, suggesting thatthey have evolved from an ancestral gene which was fused to the OPRTasegene in D. discoideum. It is less related to the bacterial enzyme but allthese sequences present conserved blocks of homology which could identifythe active site. The codon usage is strongly biased in a manner similar tothat found for other D. discoideum genes. The flanking DNA containshomopolymers of A and T and alternating sequences that are characteristicof the gene organization in D. discoideum.
- Structure (3D structures containing this domain)
3D Structures of OMPdecase domains in PDB
PDB code Main view Title 1dbt CRYSTAL STRUCTURE OF OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE FROM BACILLUS SUBTILIS COMPLEXED WITH UMP 1dqw CRYSTAL STRUCTURE OF OROTIDINE 5'-PHOSPHATE DECARBOXYLASE 1dqx CRYSTAL STRUCTURE OF OROTIDINE 5'-PHOSPHATE DECARBOXYLASE COMPLEXED TO 6-HYDROXYURIDINE 5'-PHOSPHATE (BMP) 1dv7 CRYSTAL STRUCTURE OF OROTIDINE MONOPHOSPHATE DECARBOXYLASE 1dvj CRYSTAL STRUCTURE OF OROTIDINE MONOPHOSPHATE DECARBOXYLASE COMPLEXED WITH 6-AZAUMP 1eix STRUCTURE OF OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE FROM E. COLI, CO-CRYSTALLISED WITH THE INHIBITOR BMP 1jjk Selenomethionine Substitution of Orotidine-5'-monophosphate Decarboxylase from E. coli Causes a Change in Crystal Contacts and Space Group 1kly Orotidine monophosphate decarboxylase D70G mutant complexed with 6-azaUMP 1klz Crystal structure of orotidine monophosphate decarboxylase mutant D70A complexed with UMP 1km0 Crystal structure of orotidine monophosphate decarboxylase mutant D70N complexed with 6-azaUMP 1km1 Orotidine monophosphate decarboxylase mutant S127A crystal structure 1km2 crystal structure of orotidine monophosphate mutant Q185A with 6-azaUMP 1km3 crystal structure of ODCase mutant K42A complexed with 6-azaUMP 1km4 crystal structure of ODCase mutant K72A complexed with UMP 1km5 Crystal structure of ODCase mutant D75N complexed with 6-azaUMP 1km6 Crystal structure of ODCase mutant D70AK72A complexed with OMP 1kv8 Crystal Structure of 3-Keto-L-Gulonate 6-Phosphate Decarboxylase 1kw1 Crystal Structure of 3-Keto-L-Gulonate 6-Phosphate Decarboxylase with bound L-gulonate 6-phosphate 1l2u Orotidine 5'-monophosphate decarboxylase from E. coli 1lol Crystal structure of orotidine monophosphate decarboxylase complex with XMP 1loq Crystal structure of orotidine monophosphate decarboxylase complexed with product UMP 1lor crystal structure of orotidine 5'-monophosphate complexed with BMP 1los crystal structure of orotidine monophosphate decarboxylase mutant deltaR203A complexed with 6-azaUMP 1lp6 Crystal structure of orotidine monophosphate decarboxylase complexed with CMP 1q6l Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-threonohydroxamate 4-phosphate 1q6o Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-gulonaet 6-phosphate 1q6q Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound xylitol 5-phosphate 1q6r Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-xylulose 5-phosphate 1so3 Crystal structure of H136A mutant of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-threonohydroxamate 4-phosphate 1so4 Crystal structure of K64A mutant of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-threonohydroxamate 4-phosphate 1so5 Crystal structure of E112Q mutant of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-threonohydroxamate 4-phosphate 1so6 Crystal structure of E112Q/H136A double mutant of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-threonohydroxamate 4-phosphate 1vqt Crystal structure of Orotidine 5'-phosphate decarboxylase (TM0332) from Thermotoga maritima at 2.00 A resolution 1x1z Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump) 1xbv Crystal structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound D-ribulose 5-phosphate 1xbx Structure of 3-keto-L-gulonate 6-phosphate decarboxylase E112D/R139V/T169A mutant with bound D-ribulose 5-phosphate 1xby Structure of 3-keto-L-gulonate 6-phosphate decarboxylase E112D/T169A mutant with bound D-ribulose 5-phosphate 1xbz Crystal structure of 3-keto-L-gulonate 6-phosphate decarboxylase E112D/R139V/T169A mutant with bound L-xylulose 5-phosphate 2aqw Structure of putative orotidine-monophosphate-decarboxylase from Plasmodium yoelii (PY01515) 2cz5 Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 2czd Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 at 1.6 A resolution 2cze Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 complexed with UMP 2czf Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 complexed with XMP 2e6y Covalent complex of orotidine 5'-monophosphate decarboxylase (ODCase) with 6-Iodo-UMP 2eaw Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase) 2f84 Crystal Structure of an orotidine-5'-monophosphate decarboxylase homolog from P.falciparum 2fds Crystal Structure of Plasmodium Berghei Orotidine 5'-monophosphate Decarboxylase (ortholog of Plasmodium falciparum PF10_0225) 2ffc Crystal Structure of Plasmodium Vivax Orotidine-Monophosphate-Decarboxyl UMP Bound 2guu crystal structure of Plasmodium vivax orotidine 5-monophosphate decarboxylase with 6-aza-UMP bound 2jgy The crystal structure of human orotidine-5'-decarboxylase domain of human uridine monophosphate synthetase (UMPS) 2p1f Human UMP Synthase (C-terminal Domain-Orotidine 5'-Monophosphate Decarboxylase) 2q8l Crystal structure of orotidine 5'-phosphate decarboxylase from Plasmodium falciparum 2q8z Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase complexed with 6-amino-UMP 2qaf Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase covalently modified by 6-iodo-UMP 2qcc Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase, apo form 2qcd Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to UMP 2qce Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to sulfate, glycerol, and chloride 2qcf Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 5-fluoro-UMP 2qcg Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to 5-bromo-UMP 2qch Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to 5-iodo-UMP 2qcl Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to OMP 2qcm Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 6-hydroxymethyl-UMP 2qcn Covalent complex of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase with 6-iodo-UMP 2v30 Human orotidine 5'-phosphate decarboxylase domain of uridine monophospate synthetase (UMPS) in complex with its product UMP. 2yyt Crystal structure of uncharacterized conserved protein from Geobacillus kaustophilus 2yyu Crystal structure of uncharacterized conserved protein from Geobacillus kaustophilus 2za1 Crystal Structure of orotidine 5'-monophosphate decarboxylase complexed with orotidine 5'-monophosphate from P.falciparum 2za2 Crystal Structure of the apo-form of orotidine-5'-monophosphate decarboxylase from P.falciparum 2za3 Crystal Structure of orotidine 5'-monophosphate decarboxylase complexed with uridine 5'-monophosphate from P.falciparum 2zcg Structure and inhibition of orotidine 5'-phosphate decarboxylase from plasmodium falciparum 2zz1 Snapshot of the reaction from 6-CN-UMP to BMP catalyzed by Orotidine Monophosphate Deacarboxylase from M. thermoautotrophicum 2zz2 Orotidine Monophosphate Decarboxylase K72A mutant from M. thermoautotrophicum complexed with 6-cyano-UMP 2zz3 Covalent complex of orotidine monophosphate decarboxylase D70A mutant from M. thermoautotrophicus with 6-cyano-UMP 2zz4 Covalent complex of orotidine monophosphate decarboxylase D75N mutant from M. thermoautotrophicum with 6-cyano-UMP 2zz5 Orotidine Monophosphate Deacarboxylase D70A/K72A double mutant from M. thermoautotrophicum complexed with 6- cyano-UMP 2zz6 Covalent complex of orotidine monophosphate decarboxylase from M. thermoautotrophicum with 6-azido-UMP 2zz7 Orotidine Monophosphate Decarboxylase K72A mutant complexed with BMP (produced from 6-Iodo-UMP) 3ajx Crystal Structure of 3-Hexulose-6-Phosphate Synthase 3bar Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase covalently modified by 6-azido-UMP 3bgg Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP 3bgj Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 6-iodo-UMP 3bk0 Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP 3bpw Crystal Structure of P. falciparum Orotidine 5'-monophosphate Decarboxylase Complexed with XMP 3bvj Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with XMP 3dbp Crystal Structure of Human Orotidine 5'-Monophosphate Decarboxylase Complexed with 6-NH2-UMP 3ewu D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP, covalent adduct 3eww D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-UMP, covalent adduct 3ewx K314A mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, degraded to BMP 3ewy K314A mutant of human orotidyl-5'-monophosphate decarboxylase soaked with OMP, decarboxylated to UMP 3ewz human orotidyl-5'-monophosphate decarboxylase in complex with 5-cyano-UMP 3ex1 human orotidyl-5'-monophosphate decarboxylase soaked with 6-cyano-UMP, converted to UMP 3ex2 human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-UMP 3ex3 human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent adduct 3ex4 human orotidyl-5'-monophosphate decarboxylase in complex with BMP 3ex6 D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent adduct 3exr Crystal structure of KGPDC from Streptococcus mutans 3exs Crystal structure of KGPDC from Streptococcus mutans in complex with D-R5P 3ext Crystal structure of KGPDC from Streptococcus mutans 3f4w The 1.65A Crystal Structure of 3-hexulose-6-phosphate synthase from Salmonella typhimurium 3g18 Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum 3g1a Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-azauridine 5'-monophosphate 3g1d Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with uridine 5'-monophosphate 3g1f Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 5,6-dihydroorotidine 5'-monophosphate 3g1h Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 5,6-dihydrouridine 5'-monophosphate 3g1s Crystal structure of the mutant D70G of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum 3g1v Crystal structure of the mutant D70G of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 5-fluorouridine 5'-monophosphate 3g1x Crystal structure of the mutant D70G of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with uridine 5'-monophosphate 3g1y Crystal structure of the mutant D70N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with sulfate 3g22 Crystal structure of the mutant D70N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with uridine 5'-monophosphate 3g24 Crystal structure of the mutant D70N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-azauridine 5'-monophosphate 3g3d Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-azido-UMP 3g3m Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-iodo-UMP 3gdk Crystal structure of the orotidine 5'-monophosphate decarboxylase from Saccharomyces cerevisiae 3gdl Crystal structure of the orotidine 5'-monophosphate decarboxylase from Saccharomyces cerevisiae complexed with 6-azauridine 5'-monophosphate 3gdm Crystal structure of the K93R mutant of the orotidine 5'-monophosphate decarboxylase from Saccharomyces cerevisiae 3gdr Crystal structure of the D91N mutant of the orotidine 5'-monophosphate decarboxylase from Saccharomyces cerevisiae 3gdt Crystal structure of the D91N mutant of the orotidine 5'-monophosphate decarboxylase from Saccharomyces cerevisiae complexed with 6-azauridine 5'-monophosphate 3ieb Crystal structure of 3-keto-L-gulonate-6-phosphate decarboxylase from Vibrio cholerae O1 biovar El Tor str. N16961 3jr2 X-ray crystal structure of the Mg-bound 3-keto-L-gulonate-6-phosphate decarboxylase from Vibrio cholerae O1 biovar El Tor str. N16961 3l0k Human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP 3l0n Human orotidyl-5'-monophosphate decarboxylase in complex with 6-mercapto-UMP 3ldv 1.77 Angstrom resolution crystal structure of orotidine 5'-phosphate decarboxylase from Vibrio cholerae O1 biovar eltor str. N16961 3lht Crystal structure of the mutant V201F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3lhu Crystal structure of the mutant I199F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3lhv Crystal structure of the mutant V182A.I199A.V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3lhw Crystal structure of the mutant V182A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3lhy Crystal structure of the mutant I199A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3lhz Crystal structure of the mutant V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3li0 Crystal structure of the mutant R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3li1 Crystal structure of the mutant I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3lld Crystal structure of the mutant S127G of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-azauridine 5'-monophosphate 3llf Crystal structure of the mutant S127P of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-azauridine 5'-monophosphate 3ltp Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3lts Crystal structure of the mutant V182A,I199A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3lty Crystal structure of the mutant V182A,I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3lv5 Crystal structure of the mutant I199E of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3lv6 Crystal structure of the mutant I218F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3m1z Crystal structure of the mutant V182A.V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3m41 Crystal structure of the mutant V182A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum 3m43 Crystal structure of the mutant I199A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum 3m44 Crystal structure of the mutant V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum 3m47 Crystal structure of the mutant I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum 3m5x Crystal structure of the mutant V182A,I199A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum 3m5y Crystal structure of the mutant V182A,V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum 3m5z Crystal structure of the mutant V182A,I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum 3mi2 Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate 3mo7 Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by 2'-fluoro-6-iodo-UMP 3mw7 Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-UMP(produced from 5-fluoro-6-amino-UMP) 3mwa Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase covalently modified by 2-prime-fluoro-6-iodo-UMP 3n2m Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP 3n34 Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP, produced from 5-fluoro-6-azido-UMP 3n3m Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase complexed with 6-amino-UMP 3nq6 Crystal structure of the mutant P180A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor 6-azaUMP 3nq7 Crystal structure of the mutant F71A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3nqa Crystal structure of the mutant F100A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3nqc Crystal structure of the mutant I96S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3nqd Crystal structure of the mutant I96T of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3nqe Crystal structure of the mutant L123N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3nqf Crystal structure of the mutant L123S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3nqg Crystal structure of the mutant V155D of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3nqm Crystal structure of the mutant V155S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3p5y Crystal structure of the mutant T159A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3p5z Crystal structure of the mutant T159S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3p60 Crystal structure of the mutant T159V of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3p61 Crystal structure of the mutant R160A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 3pbu Crystal structure of the mutant I96S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-azauridine 5'-monophosphate 3pbv Crystal structure of the mutant I96T of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-azauridine 5'-monophosphate 3pbw Crystal structure of the mutant L123N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-azauridine 5'-monophosphate 3pby Crystal structure of the mutant L123S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-azauridine 5'-monophosphate 3pc0 Crystal structure of the mutant V155S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-azauridine 5'-monophosphate 3qez Crystal structure of the mutant T159V,V182A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 3qf0 Crystal structure of the mutant T159V,Y206F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 3qmr Crystal structure of the mutant R160A,V182A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 3qms Crystal structure of the mutant T159V,V182A,Y206F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 3qmt Crystal structure of the mutant V182A,Y206F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 3qw3 Structure of Leishmania donovani OMP decarboxylase 3qw4 Structure of Leishmania donovani UMP synthase 3r89 Crystal structure of orotidine 5-phosphate decarboxylase from Anaerococcus prevotii DSM 20548 3rlu Crystal structure of the mutant K82A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 3rlv Crystal structure of the mutant Y206F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 3ru6 1.8 Angstrom resolution crystal structure of orotidine 5'-phosphate decarboxylase (pyrF) from Campylobacter jejuni subsp. jejuni NCTC 11168 3s9y Crystal Structure of P. falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP in space group P21, produced from 5-fluoro-6-azido-UMP 3sec Crystal structure of Methanothermobacter thermautotrophicus orotidine 5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate 3sgu Crystal structure of Methanothermobacter thermautotrophicus orotidine 5'-monophosphate decarboxylase covalently modified by 5-fluoro-6-iodo-UMP 3siz Crystal structure of the mutant S127A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 3sj3 Crystal structure of the mutant R160A.Y206F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 3ssj Crystal structure of Methanothermobacter thermautotrophicus orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP 3sw6 Crystal structure of Methanothermobacter thermautotrophicus orotidine 5'-monophosphate decarboxylase covalently modified by 5-fluoro-6-azido-UMP 3sy5 Crystal structure of the mutant S127A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor 6azaUMP 3tfx Crystal structure of Orotidine 5'-phosphate decarboxylase from Lactobacillus acidophilus 3thq Crystal structure of Methanothermobacter thermautotrophicus orotidine 5'-monophosphate decarboxylase complexed with 6-amino-UMP 3tr2 Structure of a orotidine 5'-phosphate decarboxylase (pyrF) from Coxiella burnetii 3uwq 1.80 Angstrom resolution crystal structure of orotidine 5'-phosphate decarboxylase from Vibrio cholerae O1 biovar eltor str. N16961 in complex with uridine-5'-monophosphate (UMP) 3v1p Crystal structure of the mutant Q185A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 3v75 Crystal structure of putative orotidine 5'-phosphate decarboxylase from Streptomyces avermitilis ma-4680 3ve7 Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula complexed with inhibitor BMP 3ve9 Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula 3vi2 Crystal Structure Analysis of Plasmodium falciparum OMP Decarboxylase in complex with inhibitor HMOA 3w07 Atomic resolution structure of orotidine 5'-monophosphate decarboxylase from Methanothermobacter thermoautotrophicus bound with UMP. 3wjw Wild-type orotidine 5'-monophosphate decarboxylase from M. thermoautotrophicus complexed with 6-methyl-UMP 3wjx Wild-type orotidine 5'-monophosphate decarboxylase from M. thermoautotrophicus complexed with 6-amino-UMP 3wjy Orotidine 5'-monophosphate decarboxylase K72A mutant from M. thermoautotrophicus complexed with 6-amino-UMP 3wjz Orotidine 5'-monophosphate decarboxylase D75N mutant from M. thermoautotrophicus complexed with 6-amino-UMP 3wk0 Wild-type orotidine 5'-monophosphate decarboxylase from M. thermoautotrophicus complexed with orotidine 5'-monophosphate methyl ester 3wk1 Wild-type orotidine 5'-monophosphate decarboxylase from M. thermoautotrophicus complexed with orotidine 5'-monophosphate ethyl ester 3wk2 Orotidine 5'-monophosphate decarboxylase K72A mutant from M. thermoautotrophicus complexed with orotidine 5'-monophosphate methyl ester 3wk3 Orotidine 5'-monophosphate decarboxylase K72A mutant from M. thermoautotrophicus complexed with orotidine 5'-monophosphate ethyl ester 4dbd Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus 4dbe Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus complexed with inhibitor BMP 4df0 Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus 4df1 Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus complexed with inhibitor BMP 4fx6 Crystal structure of the mutant V182A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 4fx8 Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 4fxr Crystal structure of the mutant T159V.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 4gc4 Crystal structure of the mutant R160A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 4hib Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH 4hkp Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxide 4lc6 Crystal structure of the mutant H128Q of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 4lc8 Crystal structure of the mutant H128N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 4lui Crystal structure of Orotidine 5'-monophosphate decarboxylase from methanocaldococcus jannaschii 4luj Crystal structure of Orotidine 5'-monophosphate decarboxylase from methanocaldococcus jannaschii complexed with inhibitor BMP 4lw7 4LW7 4mjz 2.75 Angstrom Resolution Crystal Structure of Putative Orotidine-monophosphate-decarboxylase from Toxoplasma gondii. 4muz Crystal structure of orotidine 5'-monophosphate decarboxylase from Archaeoglobus fulgidus complexed with inhibitor BMP 4n2y Crystal structure of orotidine 5'-monophosphate decarboxylase from Archaeoglobus fulgidus 4nt0 Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 3-deazauridine 5'-monophosphate 4nuw Crystal structure of orotidine 5'-monophosphate decarboxylase from methanobacterium thermoautotrophicum complexed with uridine 5'-monophosphate 4nx5 Crystal structure of orotidine 5'-monophosphate decarboxylase from methanobacterium thermoautotrophicum complexed with 6-azauridine 5'-monophosphate 4o11 Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-hydroxyuridine 5'-monophosphate 4o8r Crystal structure of orotidine 5'-monophosphate decarboxylase from methanobacterium thermoautotrophicum complexed with 5,6-dihydrouridine 5'-monophosphate - Links (links to other resources describing this domain)
-
INTERPRO IPR001754 PFAM OMPdecase