Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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PA14

SMART accession number:	SM00758
Description:	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins.
Interpro abstract (IPR011658):	The PA14 domain forms an insert in bacterial beta-glucosidases, other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium pre-spore cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding [(PUBMED:15236739)].
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 760 PA14 domains in 679 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a PA14 domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with PA14 domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Rigden DJ, Mello LV, Galperin MY
  • The PA14 domain, a conserved all-beta domain in bacterial toxins, enzymes, adhesins and signaling molecules.
  • Trends Biochem Sci. 2004; 29: 335-9
• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 25.86 map00500 Starch and sucrose metabolism 25.86 map00940 Phenylpropanoid biosynthesis 25.86 map00460 Cyanoamino acid metabolism 5.17 map00530 Aminosugars metabolism 3.45 map00604 Glycosphingolipid biosynthesis - ganglioseries 3.45 map00511 N-Glycan degradation 3.45 map00531 Glycosaminoglycan degradation 3.45 map00603 Glycosphingolipid biosynthesis - globoseries 3.45 map01032 Glycan structures - degradation This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with PA14 domain which could be assigned to a KEGG orthologous group, and not all proteins containing PA14 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of PA14 domains in PDB

  PDB code	Main view	Title
  1acc		Anthrax protective antigen
  1t6b		Crystal structure of b. anthracis protective antigen complexed with human anthrax toxin receptor
  2j42		Low quality crystal structure of the transport component c2- ii of the c2-toxin from clostridium botulinum

• Links (links to other resources describing this domain)

• PFAM	PA14
  INTERPRO	IPR011658

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