PAHPancreatic hormones / neuropeptide F / peptide YY family
|SMART accession number:||SM00309|
|Description:||Pancreatic hormone is a regulator of pancreatic and gastrointestinal functions.|
|Interpro abstract (IPR001955):|
Pancreatic hormone (PP) [(PUBMED:6107857)] is a peptide synthesized in pancreatic islets of Langherhans, which acts as a regulator of pancreatic and gastrointestinal functions.
The hormone is produced as a larger propeptide, which is enzymatically cleaved to yield the mature active peptide: this is 36 amino acids in length [(PUBMED:3031687)] and has an amidated C terminus [(PUBMED:2599092)]. The hormone has a globular structure, residues 2-8 forming a left-handed poly-proline-II-like helix, residues 9-13 a beta turn, and 14-32 an alpha-helix,held close to the first helix by hydrophobic interactions [(PUBMED:3031687)]. Unlike glucagon, another peptide hormone, the structure of pancreatic peptide is preserved in aqueous solution [(PUBMED:2067973)]. Both N and C termini are required for activity: receptor binding and activation functions may reside in the N and C termini respectively [(PUBMED:3031687)].
Pancreatic hormone is part of a wider family of active peptides that includes:
|GO component:||extracellular region (GO:0005576)|
|GO function:||hormone activity (GO:0005179)|
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