Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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PAW domain present in PNGases and other hypothetical proteins

SMART accession number:	SM00613
Description:	present in several copies in proteins with unknown function in C. elegans
Interpro abstract (IPR006588):	The PAW domain (present in PNGases and other worm proteins) is found as a single copy at the C terminus of metazoan peptide:N-glycanase (PNGase) and in multiple copies in hypothetical Caenorhabditis elegans proteins peptide:N-glycanases (PNGases) [(PUBMED:11779830)]. The C-terminal PAW domain of PNGase binds to the mannose moieties of N-linked oligosaccharide chains [(PUBMED:17088551)]. The PAW domain is a slightly elongated molecule and displays a beta-sandwich architecture, which is composed of two layers, containing nine and eight antiparallel beta-strands, respectively, and three additional short helices [(PUBMED:17088551)]. Some proteins known to contain a PAW domain are listed below: Animal peptide:N-glycanase (PNGase) EC 3.5.1.52, catalyses the deglycosylation of several misfolded N-linked glycoproteins by cleaving the bulky glycan chain before the proteins are degraded by the proteasome. Caenorhabditis elegans putative uncharacterised protein C17B7.5.
GO process:	glycoprotein catabolic process (GO:0006516)
GO component:	cytoplasm (GO:0005737)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 91 PAW domains in 74 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a PAW domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with PAW domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Doerks T, Copley RR, Schultz J, Ponting CP, Bork P
  • Systematic identification of novel protein domain families associated with nuclear functions.
  • Genome Res. 2002; 12: 47-56
  • Display abstract

  • A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.

• Structure (3D structures containing this domain)

• 3D Structures of PAW domains in PDB

  PDB code	Main view	Title
  2g9f		Crystal structure of intein-tagged mouse pngase c-terminal domain
  2g9g		Crystal structure of his-tagged mouse pngase c-terminal domain
  2i74		Crystal structure of mouse peptide n-glycanase c-terminal domain in complex with mannopentaose

• Links (links to other resources describing this domain)

• INTERPRO	IPR006588

Send comments to Ivica Letunic