PBPb

Bacterial periplasmic substrate-binding proteins
PBPb
SMART accession number:SM00062
Description: bacterial proteins, eukaryotic ones are in PBPe
Interpro abstract (IPR001638):

Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [(PUBMED:8003968), (PUBMED:18310026)].

On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped [(PUBMED:8336670)] into eight families or clusters, which generally correlate with the nature of the solute bound.

This entry represents a domain found in the solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. This domain can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. MltF is a murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product [(PUBMED:18234673)].

Familiy 3 members include:

  • Histidine-binding protein (gene hisJ) of Escherichia coli and related bacteria. An homologous lipoprotein exists in Neisseria gonorrhoeae.
  • Lysine/arginine/ornithine-binding proteins (LAO) (gene argT) of Escherichia coli and related bacteria are involved in the same transport system than hisJ. Both solute-binding proteins interact with a common membrane-bound receptor hisP of the binding protein dependent transport system HisQMP.
  • Glutamine-binding proteins (gene glnH) of Escherichia coli and Bacillus stearothermophilus.
  • Glutamate-binding protein (gene gluB) of Corynebacterium glutamicum.
  • Arginine-binding proteins artI and artJ of Escherichia coli.
  • Nopaline-binding protein (gene nocT) from Agrobacterium tumefaciens.
  • Octopine-binding protein (gene occT) from Agrobacterium tumefaciens.
  • Major cell-binding factor (CBF1) (gene: peb1A) from Campylobacter jejuni.
  • Bacteroides nodosus protein aabA.
  • Cyclohexadienyl/arogenate dehydratase of Pseudomonas aeruginosa, a periplasmic enzyme which forms an alternative pathway for phenylalanine biosynthesis.
  • Escherichia coli protein fliY.
  • Vibrio harveyi protein patH.
  • Escherichia coli hypothetical protein ydhW.
  • Bacillus subtilis hypothetical protein yckB.
  • Bacillus subtilis hypothetical protein yckK.
Family alignment:
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There are 35313 PBPb domains in 33463 proteins in SMART's nrdb database.

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