Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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PCRF

SMART accession number:	SM00937
Description:	This domain is found in peptide chain release factors.
Interpro abstract (IPR005139):	This domain is found in peptide chain release factors. Peptide chain release factors are important for protein synthesis since they direct the termination of translation in response to the peptide chain termination codons UAG and UAA. These are structurally distinct but both contain the PCRF domain [(PUBMED:11779511)].
GO process:	translational termination (GO:0006415)
GO component:	cytoplasm (GO:0005737)
GO function:	translation release factor activity, codon specific (GO:0016149)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 3216 PCRF domains in 3216 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a PCRF domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with PCRF domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Structure (3D structures containing this domain)

• 3D Structures of PCRF domains in PDB

  PDB code	Main view	Title
  1gqe		Polypeptide chain release factor 2 (rf2) from escherichia coli
  1mi6		Docking of the modified rf2 x-ray structure into the low resolution cryo-em map of rf2 e.coli 70s ribosome
  1ml5		Structure of the e. coli ribosomal termination complex with release factor 2
  1rq0		Crystal structure of peptide releasing factor 1
  1zbt		Crystal structure of peptide chain release factor 1 (rf-1) (smu.1085) from streptococcus mutans at 2.34 a resolution
  2b3t		Molecular basis for bacterial class 1 release factor methylation by prmc
  2b64		30s ribosomal subunit, trnas, mrna and release factor rf1 from a crystal structure of the whole ribosomal complex. this file contains the 30s subunit, trnas, mrna and release factor rf1 from a crystal structure of the whole ribosomal complex". the entire crystal structure contains one 70s ribosome, trnas, mrna and release factor rf1 and is described in remark 400.
  2b9m		30s ribosomal subunit, trnas, mrna and release factor rf2 from a crystal structure of the whole ribosomal complex. this file contains the 30s ribosomal subunit, trnas, mrna and release factor rf2 from a crystal structure of the whole ribosomal complex". the entire crystal structure contains one 70s ribosome, trnas, mrna and release factor rf2 and is described in remark 400.
  2fvo		Docking of the modified rf1 x-ray structure into the low resolution cryo-em map of e.coli 70s ribosome bound with rf1
  2ihr		Rf2 of thermus thermophilus
  2wh1		Insights into translational termination from the structure of rf2 bound to the ribosome
  2wh3		Insights into translational termination from the structure of rf2 bound to the ribosome). this file contains the 30s subunit.
  3d5a		Structural basis for translation termination on the 70s ribosome. this file contains the 30s subunit, release factor 1 (rf1), two trna, and mrna molecules of one 70s ribosome. the entire crystal structure contains two 70s ribosomes as described in remark 400.
  3d5c		Structural basis for translation termination on the 70s ribosome. this file contains the 30s subunit, release factor 1 (rf1), two trna, and mrna molecules of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes as described in remark 400.
  3f1e		Crystal structure of a translation termination complex formed with release factor rf2. this file contains the 30s subunit, rf2, two trna, and mrna molecules of one 70s ribosome. the entire crystal structure contains two 70s ribosomes as described in remark 400.
  3f1g		Crystal structure of a translation termination complex formed with release factor rf2. this file contains the 30s subunit, rf2, two trna, and mrna molecules of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes as described in remark 400.

• Links (links to other resources describing this domain)

• PFAM	PCRF
  INTERPRO	IPR005139

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