Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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PCRF

SMART accession number:	SM00937
Description:	This domain is found in peptide chain release factors.
Interpro abstract (IPR005139):	This domain is found in bacterial, mitochondrial and chloroplastic peptide chain release factors. In bacteria, termination of protein synthesis depends on the type I release factors, RF1 and RF2 [ (PUBMED:2215213) ]. Both contain this domain.
GO process:	translational termination (GO:0006415)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 39330 PCRF domains in 39328 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing PCRF domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with PCRF domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing PCRF domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Structure (3D structures containing this domain)

• 3D Structures of PCRF domains in PDB

  PDB code	Main view	Title
  1gqe		Polypeptide Chain Release Factor 2 (RF2) from Escherichia coli
  1mi6		Docking of the modified RF2 X-ray structure into the Low Resolution Cryo-EM map of RF2 E.coli 70S Ribosome
  1ml5		Structure of the E. coli ribosomal termination complex with release factor 2
  1rq0		Crystal structure of peptide releasing factor 1
  1zbt		Crystal structure of Peptide chain release factor 1 (RF-1) (SMU.1085) from Streptococcus mutans at 2.34 A resolution
  2b3t		Molecular basis for bacterial class 1 release factor methylation by PrmC
  2fvo		Docking of the modified RF1 X-ray structure into the Low Resolution Cryo-EM map of E.coli 70S Ribosome bound with RF1
  2ihr		RF2 of Thermus thermophilus
  4v4r		4V4R
  4v4s		4V4S
  4v5e		4V5E
  4v5j		4V5J
  4v63		4V63
  4v67		4V67
  4v7p		4V7P
  4v9n		4V9N
  5czp		5CZP
  5dfe		5DFE
  5j30		5J30
  5j3c		5J3C
  5j4d		5J4D

• Links (links to other resources describing this domain)

• PFAM	PCRF
  INTERPRO	IPR005139

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