PDP or trefoil or TFF domain
|SMART accession number:||SM00018|
|Description:||Proposed role in renewal and pathology of mucous epithelia.|
|Interpro abstract (IPR000519):|
A cysteine-rich domain of approximately forty five amino-acid residues has been found in some extracellular eukaryotic proteins [(PUBMED:7820556), (PUBMED:9187350), (PUBMED:8518738), (PUBMED:8267796)]. It is known as either the 'P', 'trefoil' or 'TFF' domain, and contains six cysteines linked by three disulphide bonds with connectivity 1-5, 2-4, 3-6. This leads to a characteristic three leafed structure ('trefoil'). The P-type domain is clearly composed of three looplike regions. The central core of the domain consists of a short two-stranded antiparallel beta-sheet, which is capped by an irregular loop and forms a central hairpin (loop 3). The beta-sheet is preceded by a short alpha-helix, with majority of the remainder of the domain contained in two loops, which lie on either side of the central hairpin.
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- Evolution (species in which this domain is found)
- Literature (relevant references for this domain)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
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