• Links (links to other resources describing this domain)
  • PI3Ka

    Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    SMART accession number:SM00145
    Description: PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation.
    Interpro abstract (IPR001263):

    Phosphatidylinositol 3-kinase (PI3-kinase) (EC is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. The role of the accessory domain of phosphoinositide 3-kinase (PI3-kinase) is unclear. It may be involved in substrate presentation [(PUBMED:8248783)].

    Family alignment:
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    There are 1973 PI3Ka domains in 1973 proteins in SMART's nrdb database.

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