PI3Ka

Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3Ka
SMART accession number:SM00145
Description: PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation.
Interpro abstract (IPR001263):

Phosphatidylinositol 3-kinase (PI3-kinase) (EC 2.7.1.137) is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. The role of the accessory domain of phosphoinositide 3-kinase (PI3-kinase) is unclear. It may be involved in substrate presentation [(PUBMED:8248783)].

Family alignment:
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There are 1973 PI3Ka domains in 1973 proteins in SMART's nrdb database.

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