• Links (links to other resources describing this domain)
  • PI3Ka

    Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    PI3Ka
    SMART accession number:SM00145
    Description: PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation.
    Interpro abstract (IPR001263):

    Phosphatidylinositol 3-kinase (PI3-kinase) (EC 2.7.1.137) is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. The role of the accessory domain of phosphoinositide 3-kinase (PI3-kinase) is unclear. It may be involved in substrate presentation [(PUBMED:8248783)].

    Family alignment:
    View or

    There are 1973 PI3Ka domains in 1973 proteins in SMART's nrdb database.

    Click on the following links for more information.