PINc

Large family of predicted nucleotide-binding domains
PINc
SMART accession number:SM00670
Description: From similarities to 5'-exonucleases, these domains are predicted to be RNases. PINc domains in nematode SMG-5 and yeast NMD4p are predicted to be involved in RNAi.
Interpro abstract (IPR002716):

PIN domains are small protein domains identified by the presence of three strictly conserved acidic residues. Apart from these three residues, there is poor sequence conservation [(PUBMED:21036780)].

PIN domains are found in eukaryotes, eubacteria and archaea. In eukaryotes they are ribonucleases involved in nonsense mediated mRNA decay [(PUBMED:17053788)] and in processing of 18S ribosomal RNA [(PUBMED:19706509)]. In prokaryotes, they are the toxic components of toxin-antitoxin (TA) systems, their toxicity arising by virtue of their ribonuclease activity. The PIN domain TA systems are now called VapBC TAs(virulence associated proteins), where VapB is the inhibitor and VapC, the PIN-domain ribonuclease toxin [(PUBMED:21036780)].

Family alignment:
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There are 10159 PINc domains in 10121 proteins in SMART's nrdb database.

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