PINc

Large family of predicted nucleotide-binding domains
PINc
SMART accession number:SM00670
Description: From similarities to 5'-exonucleases, these domains are predicted to be RNases. PINc domains in nematode SMG-5 and yeast NMD4p are predicted to be involved in RNAi.
Interpro abstract (IPR006596):

PINc describes a large group of domains which are predicted to play a role in nucleotide-binding, potentially being found in RNases.

PINc domains in nematode SMG-5 and yeast NMD4p are predicted to be involved in the posttranscriptional gene silencing pathway known as RNA interference (RNAi). In an early step in RNAi, the initiating dsRNA is cleaved into small interfering RNAs (siRNAs), 21-23 nucleotides long, by the enzyme Dicer. After processing by Dicer, siRNAs associate with a multicomponent complex called the RNA-induced silencing complex that recognises and cleaves the cognate message [(PUBMED:12419225)].

Family alignment:
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There are 3181 PINc domains in 3180 proteins in SMART's nrdb database.

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