Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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PKS_AT Acyl transferase domain in polyketide synthase (PKS) enzymes.

SMART accession number:	SM00827
Description:
Interpro abstract (IPR020801):	Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 3743 PKS_AT domains in 2869 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a PKS_AT domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with PKS_AT domain is also avaliable.

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• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 9.55 map00632 Benzoate degradation via CoA ligation 8.99 map01053 Biosynthesis of siderophore group nonribosomal peptides 8.43 map00350 Tyrosine metabolism 8.43 map00564 Glycerophospholipid metabolism 8.43 map00960 Alkaloid biosynthesis II 8.43 map00903 Limonene and pinene degradation 8.43 map00310 Lysine degradation 8.43 map00340 Histidine metabolism 8.43 map00360 Phenylalanine metabolism 8.43 map00624 1- and 2-Methylnaphthalene degradation 8.43 map00642 Ethylbenzene degradation 2.25 map00061 Fatty acid biosynthesis 1.12 map00562 Inositol phosphate metabolism 0.56 map00860 Porphyrin and chlorophyll metabolism 0.56 map04920 Adipocytokine signaling pathway 0.56 map03320 PPAR signaling pathway 0.56 map00071 Fatty acid metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with PKS_AT domain which could be assigned to a KEGG orthologous group, and not all proteins containing PKS_AT domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of PKS_AT domains in PDB

  PDB code	Main view	Title
  2hg4		Structure of the ketosynthase-acyltransferase didomain of module 5 from debs.
  2qo3		Crystal structure of [ks3][at3] didomain from module 3 of 6- deoxyerthronolide b synthase

• Links (links to other resources describing this domain)

• INTERPRO	IPR020801

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