PSIdomain found in Plexins, Semaphorins and Integrins
|SMART accession number:||SM00423|
|Interpro abstract (IPR016201):|
This entry represents the plexin repeat, which is a disulphide-rich motif with an alpha+beta core structure that contains two conserved disulphides. This repeat motif is found in several different extracellular receptors, including plexins, which are involved in the development of neural and epithelial tissues [(PUBMED:17855350)]; in semaphorins, which regulate axon guidance, immune function and angiogenesis [(PUBMED:12958590)]; in integrins, which are important Metazoan adhesion receptors that transmit conformational change bidirectionally across the membrane (integrin alpha and beta subunits form a head and two long legs in the ectodomain and span the membrane) [(PUBMED:15378069)]; and in hepatocyte growth factor receptor, which plays important roles in normal development and in tumour growth and metastasis [(PUBMED:15167892)].
Click on the following links for more information.
- Evolution (species in which this domain is found)
- Disease (disease genes where sequence variants are found in this domain)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)