PUGdomain in protein kinases, N-glycanases and other nuclear proteins |
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| SMART accession number: | SM00580
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| Description: |
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| Interpro abstract (IPR006567): |
PUG is a domain in protein kinases, N-glycanases and other nuclear proteins found in eukaryotes.
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| GO function: | protein binding (GO:0005515) |
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| Family alignment: |
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There are 301
PUG domains in 301 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Doerks T, Copley RR, Schultz J, Ponting CP, Bork P
- Systematic identification of novel protein domain families associated with nuclear functions.
- Genome Res. 2002; 12: 47-56
- Display abstract
A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.
- Structure (3D structures containing this domain)
3D Structures of PUG domains in PDB
| PDB code | Main view | Title | | 2ccq |  | The pub domain functions as a p97 binding module in human peptide n-glycanase. |
| 2cm0 |  | The pub domain functions as a p97 binding module in human peptide n-glycanase. |
| 2d5u |  | Solution structure of the n-terminal portion of the pub domain of mouse peptide:n-glycanase |
| 2hpj |  | Crystal structure of the pub domain of mouse pngase |
| 2hpl |  | Crystal structure of the mouse p97/pngase complex |
| 2rio |  | Structure of the dual enzyme ire1 reveals the basis for catalysis and regulation of non-conventional splicing |
| 3fbv |  | Crystal structure of the oligomer formed by the kinase- ribonuclease domain of ire1 |
- Links (links to other resources describing this domain)
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