PWI

PWI, domain in splicing factors
PWI
SMART accession number:SM00311
Description: -
Interpro abstract (IPR002483):

The PWI domain, named after a highly conserved PWI tri-peptide located within its N-terminal region, is a ~80 amino acid module, which is found either at the N terminus or at the C terminus of eukaryotic proteins involved in pre-mRNA processing [(PUBMED:10322432)]. It is generally found in association with other domains such as RRM and RS. The PWI domain is a RNA/DNA-binding domain that has an equal preference for single- and double-stranded nucleic acids and is likely to have multiple important functions in pre-mRNA processing [(PUBMED:12600940)]. Proteins containing this domain include the SR-related nuclear matrix protein of 160kDa (SRm160) splicing and 3'-end cleavage-stimulatory factor, and the mammalian splicing factor PRP3.

The PWI domain is a soluble, globular and independently folded domain which consists of a four-helix bundle, with structured N- and C-terminal elements [(PUBMED:12600940)].

GO process:mRNA processing (GO:0006397)
Family alignment:
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There are 625 PWI domains in 494 proteins in SMART's nrdb database.

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