PlsC

Phosphate acyltransferases
PlsC
SMART accession number:SM00563
Description: Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.
Interpro abstract (IPR002123):

This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function [(PUBMED:9259571)]. This domain is found in tafazzins, defects in which are the cause of Barth syndrome; a severe inherited disorder which is often fatal in childhood and is characterised by cardiac and skeletal abnormalities. Phospholipid/glycerol acyltransferase is not found in the viruses or the archaea and is under represented in the bacteria. Bacterial glycerol-phosphate acyltransferases are involved in membrane biogenesis since they use fatty acid chains to form the first membrane phospholipids [(PUBMED:18369234)].

GO process:metabolic process (GO:0008152)
GO function:transferase activity, transferring acyl groups (GO:0016746)
Family alignment:
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There are 7697 PlsC domains in 7695 proteins in SMART's nrdb database.

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