Proteasome subunit A N-terminal signature Add an annotation
SMART accession number:SM00948
Description: This domain is conserved in the A subunits of the proteasome complex proteins.
Interpro abstract (IPR000426):

The proteasome (or macropain) (EC [(PUBMED:7682410), (PUBMED:2643381), (PUBMED:1317508), (PUBMED:7697118), (PUBMED:8882582)] is a eukaryotic and archaeal multicatalytic proteinase complex that seems to be involved in an ATP/ubiquitin-dependent nonlysosomal proteolytic pathway. In eukaryotes the proteasome is composed of about 28 distinct subunits which form a highly ordered ring-shaped structure (20S ring) of about 700 kDa. Most proteasome subunits can be classified on the basis of sequence similarities into two groups, alpha (A) and beta (B).

Subunits that belong to the A group are proteins of from 210 to 290 amino acids. They are classified as non-peptidase homologues in MEROPS peptidase family T1 (clan PB(T)).

This entry represents an N-terminal domain conserved in the A subunits of the proteasome complex.

GO process:ubiquitin-dependent protein catabolic process (GO:0006511)
GO component:proteasome core complex, alpha-subunit complex (GO:0019773)
GO function:endopeptidase activity (GO:0004175)
Family alignment:
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There are 3805 Proteasome_A_N domains in 3785 proteins in SMART's nrdb database.

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