Ras association (RalGDS/AF-6) domain
SMART accession number:SM00314
Description: RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Kalhammer et al. have shown that not all RA domains bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase. Predicted RA domains in PLC210 and nore1 found to bind RasGTP. Included outliers (Grb7, Grb14, adenylyl cyclases etc.)
Interpro abstract (IPR000159):

Proteins with this domain are mostly RasGTP effectors and include guanine-nucleotide releasing factor in mammals [(PUBMED:8987396)]. This factor stimulates the dissociation of GDP from the Ras-related RALA and RALB GTPases, which allows GTP binding and activation of the GTPases. It interacts and acts as an effector molecule for R-ras, K-Ras and Rap [(PUBMED:7972015)].

The domain is also present in a number of other proteins among them the sexual differentiation protein in yeast that is essential for mating and meiosis and yeast adenylate cyclase. These proteins contain repeated leucine-rich (LRR) segments.

GO process:signal transduction (GO:0007165)
Family alignment:
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There are 5524 RA domains in 5125 proteins in SMART's nrdb database.

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