Ribonuclease III family
SMART accession number:SM00535
Description: -
Interpro abstract (IPR000999):

Prokaryotic ribonuclease III (EC (gene rnc) [(PUBMED:3903434)] is an enzyme that digests double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs. RNase III is evolutionary related to a number of proteins including [(PUBMED:9241229)]:

  • Saccharomyces cerevisiae (Baker's yeast) protein pac1, a ribonuclease that probably inhibits mating and meiosis by degrading a specific mRNA required for sexual development
  • yeast ribonuclease III (gene RNT1), a dsRNA-specific nuclease that cleaves eukaryotic preribosomal RNA at various sites
  • Caenorhabditis elegans hypothetical protein F26E4.13
  • Paramecium bursaria Chlorella virus 1 (PBCV-1) 1 protein A464R
  • Synechocystis sp. (strain PCC 6803) hypothetical protein slr0346
  • yeast hypothetical protein SpAC8A4.08c, a protein with a N-terminal helicase domain and a C-terminal RNase III domain
  • C. elegans hypothetical protein K12H4.8, a protein with the same structure as SpAC8A4.08c

GO process:RNA processing (GO:0006396)
GO function:RNA binding (GO:0003723), ribonuclease III activity (GO:0004525)
Family alignment:
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There are 9364 RIBOc domains in 8342 proteins in SMART's nrdb database.

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