RICTOR_phosphoRapamycin-insensitive companion of mTOR, phosphorylation-site
|SMART accession number:||SM01309
||Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient- and growth-factor signalling. This short region is the phoshorylation site. Rictor does interact with 14-3-3 in a Thr1135-dependent manner. Rictor can be inhibited by short-term rapamycin treatment showing that Thr1135 is an mTORC1-regulated site.|
There are 298 RICTOR_phospho domains in 141 proteins in SMART's nrdb database.
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