RPEL

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
RPEL
SMART accession number:SM00707
Description: -
Interpro abstract (IPR004018):

RPEL repeat (RPxxxEL) containing proteins are found in a wide range of metazoan organisms. RPEL repeats have been shown to be required for unpolymerised actin binding and proteins containing RPEL repeats are able to modify cell shape and/or are important in the regulation of gene expression by the actin cytoskeleton. RPEL repeats can be found in association with the SAP motif, which could be involved in DNA binding [(PUBMED:12732141), (PUBMED:15620697)].

Some proteins known to contain RPEL repeats are listed below:

  • Mammalian myocardin, heart-specific serum response factor (SRF) co- activator.
  • Vertebrate myocardin-related transcription factor A (MRTF-A or MAL), a signal-regulated SRF co-activator.
  • Vertebrate myocardin-related transcription factor B (MRTF-B).
  • Mammalian phosphatase and actin regulator 1 to 3.
Family alignment:
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There are 4231 RPEL domains in 1329 proteins in SMART's nrdb database.

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