RPOLA_N

RNA polymerase I subunit A N-terminus
RPOLA_N
SMART accession number:SM00663
Description: -
Interpro abstract (IPR006592):

The task of transcribing nuclear genes is shared between three RNA polymerases in eukaryotes: RNA polymerase (pol) I synthesizes the large rRNA, pol II synthesizes mRNA and pol III synthesizes tRNA and 5S rRNA [(PUBMED:10684922)]. Pol I transcription is localised to discrete sites called nucleoli; these can be likened to ribosome factories, in which rRNA is synthesised by pol I in the fibrillar centres and then processed and assembled into ribosomes in the surrounding granular regions [(PUBMED:8689574)]. Prokaryotes, in contrast, posses a single RNA polymerase, with transcription being controlled by the particular signam factor interacting with the catalytic core.

This entry describes an N-terminal conserved region which can be found in the largest subunits of prokaryoptic and eukaryotic RNA polymerases.

GO process:transcription, DNA-templated (GO:0006351)
GO function:DNA-directed RNA polymerase activity (GO:0003899), DNA binding (GO:0003677)
Family alignment:
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There are 11081 RPOLA_N domains in 11080 proteins in SMART's nrdb database.

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