SMART: Rapamycin_bind domain annotation

Rapamycin_bind Rapamycin binding domain

SMART accession number:	SM01345
Description:	This domain forms an alpha helical structure and binds to rapamycin (PMID:8662507).
Family alignment:	View or

There are 2043 Rapamycin_bind domains in 2040 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing Rapamycin_bind domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Rapamycin_bind domain is also avaliable.

Click on the protein counts, or double click on taxonomic names to display all proteins containing Rapamycin_bind domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Choi J, Chen J, Schreiber SL, Clardy J
- Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
- Science. 1996; 273: 239-42
- Display abstract
- Rapamycin, a potent immunosuppressive agent, binds two proteins: theFK506-binding protein (FKBP12) and the FKBP-rapamycin-associated protein (FRAP). A crystal structure of the ternary complex of human FKBP12, rapamycin, and theFKBP12-rapamycin-binding (FRB) domain of human FRAP at a resolution of 2.7angstroms revealed the two proteins bound together as a result of the ability of rapamycin to occupy two different hydrophobic binding pockets simultaneously. Thestructure shows extensive interactions between rapamycin and both proteins, butfewer interactions between the proteins. The structure of the FRB domain of FRAP clarifies both rapamycin-independent and -dependent effects observed for mutants of FRAP and its homologs in the family of proteins related to theataxia-telangiectasia mutant gene product, and it illustrates how a smallcell-permeable molecule can mediate protein dimerization.
Structure (3D structures containing this domain)

Links (links to other resources describing this domain)
PFAM Rapamycin_bind

PDB code	Main view	Title
1aue		FKBP-RAPAMYCIN BINDING DOMAIN (FRB) OF THE FKBP-RAPAMYCIN ASSOCIATED PROTEIN
1fap		THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP
1nsg		THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP
2fap		THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA
2gaq		NMR SOLUTION STRUCTURE OF THE FRB DOMAIN OF mTOR
2npu		The solution structure of the rapamycin-binding domain of mTOR (FRB)
2rse		NMR structure of FKBP12-mTOR FRB domain-rapamycin complex structure determined based on PCS
3fap		ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP
3jbz		3JBZ
4drh		Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR at low pH
4dri		Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR
4drj		o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
4fap		ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP
4jsn		structure of mTORdeltaN-mLST8 complex
4jsp		structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex
4jsv		mTOR kinase structure, mechanism and regulation.
4jsx		structure of mTORDeltaN-mLST8-Torin2 complex
4jt5		mTORdeltaN-mLST8-pp242 complex
4jt6		structure of mTORDeltaN-mLST8-PI-103 complex
5flc		5FLC
5fvm		5FVM
5gpg		5GPG

Rapamycin_bind

Taxonomic distribution of proteins containing Rapamycin_bind domain.

3D Structures of Rapamycin_bind domains in PDB