RasGEF

Guanine nucleotide exchange factor for Ras-like small GTPases
RasGEF
SMART accession number:SM00147
Description:
Interpro abstract (IPR001895):

Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP [(PUBMED:1898771)]. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP [(PUBMED:8259209), (PUBMED:15335949)]. The latter proteins are known as guanine-nucleotide dissociation stimulators (GDSs) (or also as guanine-nucleotide releasing (or exchange) factors (GRFs)). Proteins that act as GDS can be classified into at least two families, on the basis of sequence similarities, the CDC24 family (see IPR001331) and the CDC25 family.

The size of the proteins of the CDC25 family range from 309 residues (LTE1) to 1596 residues (sos). The sequence similarity shared by all these proteins is limited to a region of about 250 amino acids generally located in their C-terminal section (currently the only exceptions are sos and ralGDS where this domain makes up the central part of the protein). This domain has been shown, in CDC25 an SCD25, to be essential for the activity of these proteins.

GO process:small GTPase mediated signal transduction (GO:0007264)
GO component:intracellular (GO:0005622)
GO function:guanyl-nucleotide exchange factor activity (GO:0005085)
Family alignment:
View or

There are 1626 RasGEF domains in 1626 proteins in SMART's nrdb database.

Click on the following links for more information.