S1

Ribosomal protein S1-like RNA-binding domain
S1
SMART accession number:SM00316
Description: -
Interpro abstract (IPR022967):

The S1 domain was originally identified in ribosomal protein S1 but is found in a large number of RNA-associated proteins. The structure of the S1 RNA-binding domain from the Escherichia coli polynucleotide phosphorylase has been determined using NMR methods and consists of a five-stranded antiparallel beta barrel. Conserved residues on one face of the barrel and adjacent loops form the putative RNA-binding site [(PUBMED:9008164)].

The structure of the S1 domain is very similar to that of cold shock proteins. This suggests that they may both be derived from an ancient nucleic acid-binding protein [(PUBMED:9008164)].

Family alignment:
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There are 74097 S1 domains in 45353 proteins in SMART's nrdb database.

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