Serum amyloid A proteins
SMART accession number:SM00197
Description: Serum amyloid A proteins are induced during the acute-phase response. Secondary amyloidosis is characterised by the extracellular accumulation in tissues of SAA proteins. SAA proteins are apolipoproteins.
Interpro abstract (IPR000096):

The serum amyloid A (SAA) proteins comprise a family of vertebrate proteins that associate predominantly with high density lipoproteins (HDL) [(PUBMED:7504491), (PUBMED:8188253)]. The synthesis of certain members of the family is greatly increased (as much as a 1000 fold) in inflammation; thus making SAA a major acute phase reactant. While the major physiological function of SAA is unclear, prolonged elevation of plasma SAA levels, as in chronic inflammation, however, results in a pathological condition, called amyloidosis, which affects the liver, kidney and spleen and which is characterised by the highly insoluble accumulation of SAA in these tissues. SAA are proteins of about 110 amino acid residues. The most highly conserved region is located in the central part of the sequence. The proteins are polymorphic, the various isoforms apparently capable of responding in different ways to different stimuli.

GO component:extracellular region (GO:0005576)
Family alignment:
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There are 643 SAA domains in 624 proteins in SMART's nrdb database.

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