Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

• HOME
• SETUP
• FAQ
• ABOUT
• GLOSSARY
• WHAT'S NEW
• FEEDBACK

SAF

SMART accession number:	SM00858
Description:	This domain family includes a range of different proteins. Such as antifreeze proteins and flagellar FlgA proteins, and CpaB pilus proteins.
Interpro abstract (IPR013974):	This entry includes a range of different proteins, such as antifreeze proteins, flagellar FlgA proteins, and CpaB pilus proteins [ (PUBMED:15146494) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 37399 SAF domains in 37268 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing SAF domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with SAF domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing SAF domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Structure (3D structures containing this domain)

• 3D Structures of SAF domains in PDB

  PDB code	Main view	Title
  1c89		NMR STRUCTURE OF INTRAMOLECULAR DIMER ANTIFREEZE PROTEIN RD3, 40 SA STRUCTURES
  1c8a		NMR STRUCTURE OF INTRAMOLECULAR DIMER ANTIFREEZE PROTEIN RD3, 40 SA STRUCTURES
  1ops		ICE-BINDING SURFACE ON A TYPE III ANTIFREEZE PROTEIN FROM OCEAN POUT
  1vli		Crystal structure of Spore coat polysaccharide biosynthesis protein spsE (BSU37870) from Bacillus subtilis at 2.38 A resolution
  1wvo		Solution structure of RSGI RUH-029, an antifreeze protein like domain in human N-acetylneuraminic acid phosphate synthase gene.
  1xuu		Crystal structure of sialic acid synthase (NeuB) in complex with Mn2+ and Malate from Neisseria meningitidis
  1xuz		Crystal structure analysis of sialic acid synthase (NeuB)from Neisseria meningitidis, bound to Mn2+, Phosphoenolpyruvate, and N-acetyl mannosaminitol
  2wqp		Crystal structure of sialic acid synthase NeuB-inhibitor complex
  2zdr		Crystal structure of sialic acid synthase (NeuB) from neisseria meningitidis in complex with Mg2+ and (4S)-2-methyl-2,4-pentanediol
  3cm4		Crystal structure of metal-free sialic acid synthase (NeuB) from neisseria meningitidis in complex with malate
  3frn		CRYSTAL STRUCTURE OF flagellar protein FlgA FROM Thermotoga maritima MSB8
  3g8r		Crystal structure of putative spore coat polysaccharide biosynthesis protein E from Chromobacterium violaceum ATCC 12472
  3k3s		Crystal structure of altronate hydrolase (fragment 1-84) from Shigella Flexneri.
  3laz		The crystal structure of the N-terminal domain of D-galactarate dehydratase from Escherichia coli CFT073
  3tee		Crystal Structure of Salmonella FlgA in open form
  3upl		Crystal structure of the Brucella abortus enzyme catalyzing the first committed step of the methylerythritol 4-phosphate pathway.
  3upy		Crystal structure of the Brucella abortus enzyme catalyzing the first committed step of the methylerythritol 4-phosphate pathway.
  3vjp		Orthorhombic Crystal Structure of Salmonella FlgA in closed form
  3vki		Monoclinic Crystal Structure of Salmonella FlgA in closed form
  4ipi		Crystal Structure of R314A N-acetyl Neuraminic Acid Synthase from Neiserria meningitidis with Malate bound
  4ipj		Crystal Structure of R314K N-acetyl Neuraminic Acid Synthase from Neiserria meningitidis with Malate bound
  4ur6		4UR6

• Links (links to other resources describing this domain)

• INTERPRO	IPR013974
  PFAM	SAF

Send comments to Ivica Letunic