SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains.
SMART accession number:SM00198
Description: Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.
Interpro abstract (IPR001283):

A number of eukaryotic extracellular proteins have been shown to be evolutionarily related. The family includes rodent sperm-coating glycoprotein (or acidic epididymal glycoprotein), which is thought to be involved in sperm maturation [(PUBMED:1301383)]; mammalian testis-specific protein (Tpx-1) [(PUBMED:2613236)]; glioma pathogenesis-related protein; lizard helothermine, a toxin that blocks ryanodine receptors; venom allergen 5 from vespid wasps and venom allergen 3 from fire ants, which are potent allergens that mediate allergic reactions to stings insects of the Hymenoptera family [(PUBMED:8454859)]; plant pathogenesis proteins of the PR-1 family [(PUBMED:2026137)], which are synthesised during pathogen infection or other stress-related responses; proteins Sc7 and Sc14 from the basidiomycete fungus Schizophyllum commune, which are loosely associated with fruiting body hyphal walls [(PUBMED:8245835)]; ancylostoma secreted protein from dog hookworm; and yeast hypothetical proteins YJL078c, YJL079c and YKR013w. The precise functions of these proteins is still unclear.

Family alignment:
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There are 2007 SCP domains in 1909 proteins in SMART's nrdb database.

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