Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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SFM Splicing Factor Motif, present in Prp18 and Pr04

SMART accession number:	SM00500
Description:	-
Interpro abstract (IPR014906):	This small domain is found on PRP4 ribonuleoproteins. PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing [ (PUBMED:528687) ]. It is also found in pre-mRNA-splicing factor 18 [ (PUBMED:9000057) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 1137 SFM domains in 1133 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing SFM domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with SFM domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing SFM domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: transcription
  

• Structure (3D structures containing this domain)

• 3D Structures of SFM domains in PDB

  PDB code	Main view	Title
  1mzw		Crystal structure of a U4/U6 snRNP complex between human spliceosomal cyclophilin H and a U4/U6-60K peptide
  2dk4		Solution structure of Splicing Factor Motif in Pre-mRNA splicing factor 18 (hPRP18)
  3jcm		3JCM
  3jcr		3JCR
  5gan		5GAN
  5gap		5GAP

• Links (links to other resources describing this domain)

• INTERPRO	IPR014906

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