Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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SFM Splicing Factor Motif, present in Prp18 and Pr04

SMART accession number:	SM00500
Description:
Interpro abstract (IPR003648):	The splicing factor motif is present in splicing factors including Prp18 and Pr04. In yeast, Pr04 is a U4/U6 small nuclear ribonucleoprotein involved in RNA splicing. It is required for the association of U4/U6 snRNP with U5 snRNP in an early step of spliceosome assembly.
GO process:	RNA splicing (GO:0008380)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 102 SFM domains in 102 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a SFM domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with SFM domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Cellular role (predicted cellular role)

• Cellular role: transcription
  

• Structure (3D structures containing this domain)

• 3D Structures of SFM domains in PDB

  PDB code	Main view	Title
  1mzw		Crystal structure of a u4/u6 snrnp complex between human spliceosomal cyclophilin h and a u4/u6-60k peptide
  2dk4		Solution structure of splicing factor motif in pre-mrna splicing factor 18 (hprp18)

• Links (links to other resources describing this domain)

• INTERPRO	IPR003648

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