PLAc

Cytoplasmic phospholipase A2, catalytic subunit
PLAc
SMART accession number:SM00022
Description: Cytosolic phospholipases A2 hydrolyse arachidonyl phospholipids. Family includes phospholipases B isoforms.
Interpro abstract (IPR002642): This family consists of lysophospholipase / phospholipase B EC 3.1.1.5 and cytosolic phospholipase A2 which also has a C2 domain IPR000008. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolyzing all phospholipids extractable from yeast cells [(PUBMED:8027085)]. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids [(PUBMED:8051052)], the aligned region corresponds the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in [(PUBMED:8051052)].
GO process:phospholipid catabolic process (GO:0009395)
GO function:phospholipase activity (GO:0004620)
Family alignment:
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There are 1292 PLAc domains in 1292 proteins in SMART's nrdb database.

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