|SMART accession number:||SM00088
||Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.|
|Interpro abstract (IPR000717):
||A homology domain of unclear function, occurs in the C-terminal region of several regulatory components of the 26S proteasome as well as in other proteins. This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [(PUBMED:9644972)]. Apparently, all of the characterised proteins containing PCI domains are parts of larger multi-protein complexes. Proteins with PCI domains include budding yeast proteasome regulatory components Rpn3(Sun2), Rpn5, Rpn6, Rpn7and Rpn9 [(PUBMED:9584156)]; mammalian proteasome regulatory components p55, p58 and p44.5, and translation initiation factor 3 complex subunits p110 and INT6 [(PUBMED:8995409), (PUBMED:9341143)]; Arabidopsis COP9 and FUS6/COP11 [(PUBMED:8689678)]; mammalian G-protein pathway suppressor GPS1, and several uncharacterised ORFs from plant, nematodes and mammals. The complete homology domain comprises approx. 200 residues, the highest conservation is found in the C-terminal half. Several of the proteins mentioned above have no detectable homology to the N-terminal half of the domain.
|GO function:||protein binding (GO:0005515)|
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