Thymosin beta actin-binding motif.
SMART accession number:SM00152
Description: -
Interpro abstract (IPR001152):

Thymosin beta-4 is a small polypeptide whose exact physiological role is not yet known [(PUBMED:4088087)]. It was first isolated as a thymic hormone that induces terminal deoxynucleotidyltransferase. It is found in high quantity in thymus and spleen but is widely distributed in many tissues. It has also been shown to bind to actin monomers and thus to inhibit actin polymerisation [(PUBMED:15336106)].

A number of peptides closely related to thymosin beta-4 belong to this family. They include, thymosin beta-9 (and beta-8) in Bos taurus (Bovine) and Sus scrofa (Pig), thymosin beta-10 in Homo sapiens (Human) and Rattus norvegicus (Rat), thymosin beta-11 and beta-12 in Oncorhynchus mykiss (Rainbow trout) and human Nb thymosin beta.

GO process:cytoskeleton organization (GO:0007010)
GO component:cytoplasm (GO:0005737)
GO function:actin binding (GO:0003779)
Family alignment:
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There are 1343 THY domains in 385 proteins in SMART's nrdb database.

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