THY

Thymosin beta actin-binding motif.
THY
SMART accession number:SM00152
Description: -
Interpro abstract (IPR001152):

This entry represents beta-thymosin family. Its members include thymosin beta-4, -10, -15 from humans and their homologues (such as thymosin beta 11/12) from fish.

Thymosin beta-4 (Tbeta) is a small protein that sequesters actin monomers to help maintain the high concentrations of unpolymerised actin in higher eukaryotic cells. Its structure has been resolved [(PUBMED:25313062)]. It is a multiple function protein that plays important roles in cellular processes such as wound healing, embryonic organ development and the pathogeneses of disease [(PUBMED:24993983), (PUBMED:24732964)]. It plays a role in anti-apoptotic response to an external stress [(PUBMED:15037574)], paclitaxel-resistance via ROS production [(PUBMED:18306930), (PUBMED:20637781)] and HIF-1alpha stabilisation via Erk activation [(PUBMED:18272284)]. It also regulates cancer cell migration through various signalling pathways, and hence plays a role in malignant progression and invasion in colon adenocarcinoma [(PUBMED:22328534), (PUBMED:12761500)].

Thymosin beta-15 has been reported to be up-regulated in breast, brain, lung and head and neck cancer [(PUBMED:17567946)]. The expression of thymosin beta-10 is also associated with many cancers [(PUBMED:24053380)].

GO process:actin filament organization (GO:0007015)
GO function:actin monomer binding (GO:0003785)
Family alignment:
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There are 690 THY domains in 385 proteins in SMART's nrdb database.

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