| SMART accession number: | SM00166
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| Description: |
Present in FAF1 and Shp1p. |
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| Interpro abstract (IPR001012): |
The UBX domain is found in ubiquitin-regulatory proteins, which are members of the ubiquitination pathway, as well as a number of other proteins including FAF-1 (FAS-associated factor 1), the human Rep-8 reproduction protein and several hypothetical proteins from yeast. The function of the UBX domain is not known although the fragment of avian FAF-1 containing the UBX domain causes apoptosis of transfected cells.
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| GO function: | protein binding (GO:0005515) |
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| Family alignment: |
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Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Cellular role (predicted cellular role)
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Binding / catalysis: unknown
- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Freund C, Dotsch V, Nishizawa K, Reinherz EL, Wagner G
- The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences.
- Nat Struct Biol. 1999; 6: 656-60
- Display abstract
T cell activation through the CD2 cell surface receptor is transmitted by proline-rich sequences within its cytoplasmic tail. A membrane-proximal proline-rich tandem repeat, involved in cytokine production, is recognized by the intracellular CD2 binding protein CD2BP2. We solved the solution structure of the CD2 binding domain of CD2BP2, which we name the glycine-tyrosine-phenylalanine (GYF) domain. The GYF sequence is part of a structurally unique bulge-helix-bulge motif that constitutes the major binding site for the CD2 tail. A hydrophobic surface patch is created by motif residues that are highly conserved among a variety of proteins from diverse eukaryotic species. Thus, the architecture of the GYF domain may be widely used in protein-protein associations.
- Hofmann K, Bucher P
- The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway.
- Trends Biochem Sci. 1996; 21: 172-3
- Structure (3D structures containing this domain)
3D Structures of UBX domains in PDB
| PDB code | Main view | Title | | 1h8c |  | Ubx domain from human faf1 |
| 1i42 |  | Nmr structure of the ubx domain from p47 |
| 1jru |  | Nmr structure of the ubx domain from p47 (energy minimised average) |
| 1s3s |  | Crystal structure of aaa atpase p97/vcp nd1 in complex with p47 c |
| 1wj4 |  | Solution structure of the ubx domain of kiaa0794 protein |
| 2cr5 |  | Solution structure of the ubx domain of d0h8s2298e protein |
| 2dzk |  | Structure of the ubx domain in mouse ubx domain-containing protein 2 |
- Links (links to other resources describing this domain)
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to expand nodes. To display all proteins with a UBX domain in a specific node, click on it.