Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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IL10 Interleukin-10 family

SMART accession number:	SM00188
Description:	Interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells.
Interpro abstract (IPR020443):	Interleukin-10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. Structurally, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds [(PUBMED:8590020)]. IL-10 is highly similar to the Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) BCRF1 protein which inhibits the synthesis of gamma-interferon and to Equid herpesvirus 2 (Equine herpesvirus 2) protein E7. It is also similar, but to a lesser degree, with human protein mda-7 [(PUBMED:8545104)], a protein which has antiproliferative properties in human melanoma cells. Mda-7 only contains two of the four cysteines of IL-10.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 159 IL10 domains in 159 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a IL10 domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with IL10 domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Metabolism (metabolic pathways involving proteins which contain this domain)

• % proteins involved KEGG pathway ID Description 76.67 map04060 Cytokine-cytokine receptor interaction 23.33 map04660 T cell receptor signaling pathway This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with IL10 domain which could be assigned to a KEGG orthologous group, and not all proteins containing IL10 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of IL10 domains in PDB

  PDB code	Main view	Title
  1ilk		Interleukin-10 crystal structure reveals the functional dimer with an unexpected topological similarity to interferon gamma
  1inr		Cytokine synthesis
  1j7v		Human il-10 / il-10r1 complex
  1lk3		Engineered human interleukin-10 monomer complexed to 9d7 fab fragment
  1lqs		Crystal structure of human cytomegalovirus il-10 bound to soluble human il-10r1
  1m4r		Crystal structure of recombinant human interleukin-22
  1n1f		Crystal structure of human interleukin-19
  1vlk		Structure of viral interleukin-10
  1y6k		Crystal structure of human il-10 complexed with the soluble il-10r1 chain
  1y6m		Crystal structure of epstein-barr virus il-10 complexed with the soluble il-10r1 chain
  1y6n		Crystal structure of epstein-barr virus il-10 mutant (a87i) complexed with the soluble il-10r1 chain
  1ykb		Crystal structure of insect cell expressed il-22
  2h24		Crystal structure of human il-10
  2ilk		Crystal structure of human interleukin-10 at 1.6 angstroms resolution
  3dgc		Structure of il-22/il-22r1
  3dlq		Crystal structure of the il-22/il-22r1 complex
  3g9v		Crystal structure of a soluble decoy receptor il-22bp bound to interleukin-22

• Links (links to other resources describing this domain)

• BLOCKS	INTERLEUKIN_10
  PFAM	Interleukin10
  INTERPRO	IPR020443
  PROSITE	INTERLEUKIN_10

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