SMART: THN domain annotation

THN Thaumatin family

SMART accession number:	SM00205
Description:	The thaumatin family gathers proteins related to plant pathogenesis. The thaumatin family includes very basic members with extracellular and vacuolar localization. Thaumatin itsel is a potent sweet-tasting protein. Several members of this family display significant in vitro activity of inhibiting hyphal growth or spore germination of various fungi probably by a membrane permeabilizing mechanism.
Interpro abstract (IPR001938):	Thaumatin [(PUBMED:7049841)] is an intensely sweet-tasting protein, 100 000 times sweeter than sucrose on a molar basis [(PUBMED:7049841)] found in berries from Thaumatococcus daniellii, a tropical flowering plant known as Katemfe, it is induced by attack by viroids, which are single-stranded unencapsulated RNA molecules that do not code for protein. Thaumatin consists of about 200 residues and contains 8 disulphide bonds. Like other PR proteins, thaumatin is predicted to have a mainly beta structure, with a high content of beta-turns and little helix [(PUBMED:7049841)]. Several stress-induced proteins of plants have been found to be related to thaumatins: A maize alpha-amylase/trypsin inhibitor Two tobacco pathogenesis-related proteins: PR-R major and minor forms,which are induced after infection with viruses Salt-induced protein NP24 from tomato Osmotin, a salt-induced protein from tobacco [(PUBMED:16666857)] Osmotin-like proteins OSML13, OSML15 and OSML81 from potato [(PUBMED:7630973)] P21, a leaf protein from soybean PWIR2, a leaf protein from wheat [(PUBMED:1650615)] Zeamatin, a maize antifunal protein [(PUBMED:7846159)] This protein is also referred to as pathogenesis-related group 5 (PR5), as many thaumatin-like proteins accumulate in plants in response to infection by a pathogen and possess antifungal activity [(PUBMED:1463856)]. The proteins are involved in systematically acquired resistance and stress response in plants, although their precise role is unknown [(PUBMED:1463856)].
Family alignment:	View or

There are 479 THN domains in 478 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with THN domain is also avaliable.

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Go to specific node: Arabidopsis thaliana, Caenorhabditis elegans
Structure (3D structures containing this domain)

3D Structures of THN domains in PDB

PDB code	Main view	Title
1aun		Pathogenesis-related protein 5d from nicotiana tabacum
1du5		The crystal structure of zeamatin.
1kwn		1.2 a structure of thaumatin crystallized in gel
1lr2		Crystal structure of thaumatin at high hydrostatic pressure
1lr3		Crystal structure of thaumatin at high hydrostatic pressure
1lxz		Structure of thaumatin crystallized in the presence of glycerol
1ly0		Structure of thaumatin crystallized in the presence of glycerol
1pcv		Crystal structure of osmotin, a plant antifungal protein
1pp3		Structure of thaumatin in a hexagonal space group
1rqw		Thaumatin structure at 1.05 a resolution
1thi		Crystal structures of two intensely sweet proteins
1thu		The structures of three crystal forms of the sweet protein thaumatin
1thv		The structures of three crystal forms of the sweet protein thaumatin
1thw		The structures of three crystal forms of the sweet protein thaumatin
1z3q		Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7a
2a7i		On the routine use of soft x-rays in macromolecular crystallography, part iii- the optimal data collection wavelength
2ahn		High resolution structure of a cherry allergen pru av 2
2blr		Thaumatin before a high dose x-ray "burn"
2blu		Thaumatin after a high dose x-ray "burn"
2d8o		Structure of vil-thaumatin
2d8p		Structure of hyper-vil-thaumatin
2g4y		Structure of thaumatin at 2.0 a wavelength
2i0w		Crystal structure analysis of np24-i, a thaumatin-like protein
2oqn		High pressure cryocooling of capillary sample cryoprotection and diffraction phasing at long wavelengths
2pe7		Thaumatin from thaumatococcus danielli in complex with tris- dipicolinate europium
2vhk		Atomic resolution (0.94 a) structure of purified thaumatin i grown in sodium l-tartrate at 22c
2vhr		Atomic resolution (0.95a) structure of purified thaumatin i grown in sodium l-tartrate at 4 c
2vi1		Atomic resolution (1.04 a) structure of purified thaumatin i grown in sodium d-tartrate at 22 c.
2vi2		Atomic resolution (1.05 a) structure of purified thaumatin i grown in sodium d-tartrate at 4c
2vi3		Atomic resolution (0.98 a) structure of purified thaumatin i grown in sodium dl-tartrate at 20 c
2vi4		Atomic resolution (1.10 a) structure of purified thaumatin i grown in sodium dl-tartrate at 6 c.
2vu6		Atomic resolution (0.95 a) structure of purified thaumatin i grown in sodium meso-tartrate at 19 c.
2vu7		Atomic resolution (1.08 a) structure of purified thaumatin i grown in sodium meso-tartrate at 4 c
2wbz		1.6 a structure of thaumatin crystallized without tartrate at 4 c
3dzn		Thaumatin by lb nanotemplate method before high x-ray dose on esrf id29 beamline
3dzp		Thaumatin by lb nanotemplate method after high x-ray dose on esrf id29 beamline
3dzr		Thaumatin by classical hanging drop method before high x-ray dose on esrf id29 beamline
3e0a		Thaumatin by classical hanging drop method after high x-ray dose on esrf id29 beamline
3e3s		Structure of thaumatin with the magic triangle i3c

Links (links to other resources describing this domain)
BLOCKS THAUMATIN
PFAM Thaumatinfamily
INTERPRO IPR001938
PROSITE THAUMATIN

BLOCKS	THAUMATIN
PFAM	Thaumatinfamily
INTERPRO	IPR001938
PROSITE	THAUMATIN