UBQ

Ubiquitin homologues
UBQ
SMART accession number:SM00213
Description: Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression
Interpro abstract (IPR000626):

Ubiquitin is a protein of 76 amino acid residues, found in all eukaryotic cells and whose sequence is extremely well conserved from protozoan to vertebrates. Ubiquitin acts through its post-translational attachment (ubiquitinylation) to other proteins, where these modifications alter the function, location or trafficking of the protein, or targets it for destruction by the 26S proteasome [(PUBMED:15454246)].

Ubiquitin is a globular protein, the last four C-terminal residues (Leu-Arg-Gly-Gly) extending from the compact structure to form a 'tail', important for its function. The latter is mediated by the covalent conjugation of ubiquitin to target proteins, by an isopeptide linkage between the C-terminal glycine and the epsilon amino group of lysine residues in the target proteins.

This entry represents a domain characteristic of ubiquitin (Ub) and ubiquitin-like (Ubl) proteins such as SUMO [(PUBMED:17491593), (PUBMED:15479240)] and Nedd8 [(PUBMED:9857030)].

GO function:protein binding (GO:0005515)
Family alignment:
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There are 14977 UBQ domains in 12015 proteins in SMART's nrdb database.

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