ZPZona pellucida (ZP) domain
|SMART accession number:||SM00241|
|Description:||ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).|
|Interpro abstract (IPR001507):|
The zona pellucida (ZP) domain is a protein polymerisation module of ~260 amino acid module, which is found at the C terminus of many secreted eukaryotic glycoproteins that play fundamental roles in development, hearing, immunity, and cancer [(PUBMED:1313375), (PUBMED:12021773), (PUBMED:12878193), (PUBMED:15079052)]. Proteins containing a ZP domain include:
Most ZP domain proteins are synthesized as precursors with carboxy-terminal transmembrane domains or glycosyl phosphatidylinositol (GPI) anchors [(PUBMED:12021773)].
The ZP domain contains eight strictly conserved cysteines, which form disulphide bridges. The disulphide bonds within the ZP domains are divided into two groups, suggesting that the ZP domain consists of two subdomains. In addition to the conserved cysteines, only a few aromatic or hydrophobic amino acids are absolutely invariant, probably as a result of structural rather than functional constraints [(PUBMED:1313375), (PUBMED:12878193), (PUBMED:15079052)].
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