HintC

Hint (Hedgehog/Intein) domain C-terminal region
HintC
SMART accession number:SM00305
Description: Hedgehog/Intein domain, C-terminal region. Domain has been split to accommodate large insertions of endonucleases.
Interpro abstract (IPR003586):

Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autolytic domain of the hedgehog protein of shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the hint (Hedgehog/Intein) domain [(PUBMED:9489693)].

This entry represents the C-terminal region of the hint domain.
Family alignment:
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There are 617 HintC domains in 549 proteins in SMART's nrdb database.

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