HintNHint (Hedgehog/Intein) domain N-terminal region
|SMART accession number:||SM00306|
|Description:||Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.|
|Interpro abstract (IPR003587):|
Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autolytic domain of the hedgehog protein of shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the hint (Hedgehog/Intein) domain [(PUBMED:9489693)].This entry represents the N-terminal region of the hint domain.
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- Evolution (species in which this domain is found)
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