SNcStaphylococcal nuclease homologues |
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| SMART accession number: | SM00318 |
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| Description: | |
| Interpro abstract (IPR006021): | Staphylococcus aureus nuclease (SNase) homologues, previously thought to be restricted to bacteria and archaea, are also in eukaryotes. Staphylococcal nuclease has multidomain organisation [(PUBMED:9003410)]. The human cellular coactivator p100 contains four repeats, each of which is a SNase homologue. These repeats are unlikely to possess SNase-like activities as each lacks equivalent SNase catalytic residues, yet they may mediate p100's single-stranded DNA-binding function [(PUBMED:9041650)]. alA variety of proteins including many that are still uncharacterised belong to this group. |
| GO function: | hydrolase activity, acting on ester bonds (GO:0016788), nucleic acid binding (GO:0003676) |
| Family alignment: |
There are 1525 SNc domains in 1041 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes - Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Ponting CP
- P100, a transcriptional coactivator, is a human homologue of staphylococcal nuclease.
- Protein Sci. 1997; 6: 459-63
- Display abstract
Staphylococcus aureus nuclease (SNase) homologues, previously thought to be restricted to bacteria and archaea, are demonstrated by sequence analysis to be present also in eukaryotes. The human cellular coactivator p100 is shown to contain four repeats, each of which is a SNase homologue. Surprisingly, these repeats are unlikely to possess SNase-like activities as each lacks equivalent SNase catalytic residues, yet they may mediate p100's single-stranded DNA-binding function. Products of Corydalis sempervirens and Saccharomyces cerevisiae open reading frames are predicted to adopt the same fold and possess similar functions as SNase. Five additional hypothetical proteins of bacterial origin are also predicted to be active SNase-like nucleases, including one that appears to be C-terminally truncated in a manner analogous to an engineered active SNase variant. Conservation of Asp-19 and Asp-83 among these homologues suggests a re-evaluation of the roles of these residues in Ca(2+)-binding and/or catalysis.
- Structure (3D structures containing this domain)
3D Structures of SNc domains in PDB
PDB code Main view Title 1a2t 
Staphylococcal nuclease, b-mercaptoethanol disulfide to v23c variant 1a2u 
Staphylococcal nuclease, v23c variant, complex with 1-n- butane thiol and 3',5'-thymidine diphosphate 1a3t 
Staphylococcal nuclease, v23c variant, complex with 2- fluoroethane thiol and 3',5'-thymidine diphosphate 1a3u 
Staphylococcal nuclease, cyclohexane thiol disulfide to v23c variant 1a3v 
Staphylococcal nuclease, cyclopentane thiol disulfide to v23c variant 1aex 
Staphylococcal nuclease, methane thiol disulfide to v23c variant 1ena 
Crystal structures of the binary ca2+ and pdtp complexes and the ternary complex of the asp 21->glu mutant of staphylococcal nuclease. implications for catalysis and ligand binding 1enc 
Crystal structures of the binary ca2+ and pdtp complexes and the ternary complex of the asp 21->glu mutant of staphylococcal nuclease. implications for catalysis and ligand binding 1eqv 
Simplification of a protein loop in staphylococcal nuclease 1ey0 
Structure of wild-type s. nuclease at 1.6 a resolution 1ey4 
Structure of s. nuclease stabilizing mutant s59a 1ey5 
Structure of s. nuclease stabilizing mutant t33v 1ey6 
Structure of s. nuclease stabilizing mutant t41i 1ey7 
Structure of s. nuclease stabilizing mutant s128a 1ey8 
Structure of s. nuclease stabilizing triple mutant p117g/h124l/s128a 1ey9 
Structure of s. nuclease stabilizing quadruple mutant t41i/p117g/h124l/s128a 1eya 
Structure of s. nuclease stabilizing quintuple mutant t33v/t41i/p117g/h124l/s128a 1eyc 
Structure of s. nuclease stabilizing quintuple mutant t41i/s59a/p117g/h124l/s128a 1eyd 
Structure of wild-type s. nuclease at 1.7 a resolution 1ez6 
Structure of s. nuclease stabilizing sextuple mutant t33v/t41i/s59a/p117g/h124l/s128a 1ez8 
Structure of s. nuclease stabilizing mutant t33v 1f2m 
Simplification of a protein loop in staphylococcal nuclease 1f2y 
Simplification of a protein loop in staphylococcal nuclease 1f2z 
Simplification of a protein loop in staphylococcal nuclease 1ihz 
Structure of s. nuclease mutant quintuple mutant v23l/v66l/i72l/i92l/v99l 1ii3 
Structure of s. nuclease quintuple mutant v23i/v66l/i72l/i92l/v99l 1jok 
Averaged structure for staphylococcal nuclease-h124l in ternary complex with ca2+ and thymidine-3',5'-bisphosphate 1joo 
Averaged structure for unligated staphylococcal nuclease- h124l 1joq 
Ensemble structures for staphylococcal nuclease-h124l in ternary complex with ca2+ and thymidine-3',5'-bisphosphate 1jor 
Ensemble structures for unligated staphylococcal nuclease- h124l 1kaa 
Stress and strain in staphylococcal nuclease 1kab 
Stress and strain in staphylococcal nuclease 1kda 
Stabilization of a strained protein loop conformation through protein engineering 1kdb 
Stabilization of a strained protein loop conformation through protein engineering 1kdc 
Stabilization of a strained protein loop conformation through protein engineering 1nsn 
The crystal structure of antibody n10-staphylococcal nuclease complex at 2.9 angstroms resolution 1nuc 
Staphylococcal nuclease, v23c variant 1rkn 
Solution structure of 1-110 fragment of staphylococcal nuclease with g88w mutation 1snc 
The crystal structure of the ternary complex of staphylococcal nuclease, ca2+, and the inhibitor pd*tp, refined at 1.65 angstroms 1snd 
Staphylococcal nuclease dimer containing a deletion of residues 114-119 complexed with calcium chloride and the competitive inhibitor deoxythymidine-3',5'-diphosphate 1snm 
Active site mutant glu-43 (right arrow) asp in staphylococcal nuclease displays nonlocal structural changes 1sno 
Protein stability in staphylococcal nuclease 1snp 
Protein stability in staphylococcal nuclease 1snq 
Protein stability in staphylococcal nuclease 1sta 
Accommodation of insertion mutations on the surface and in the interior of staphylococcal nuclease 1stb 
Accommodation of insertion mutations on the surface and in the interior of staphylococcal nuclease 1stg 
Two distinctly different metal binding modes are seen in x- ray crystal structures of staphylococcal nuclease- cobalt(ii)-nucleotide complexes 1sth 
Two distinctly different metal binding modes are seen in x- ray crystal structures of staphylococcal nuclease- cobalt(ii)-nucleotide complexes 1stn 
The crystal structure of staphylococcal nuclease refined at 1.7 angstroms resolution 1sty 
The alpha aneurism: a structural motif revealed in an insertion mutant of staphylococcal nuclease 1syb 
Transfer of a beta-turn structure to a new protein context 1syc 
Engineering alternative beta-turn types in staphylococcal nuclease 1syd 
Engineering alternative beta-turn types in staphylococcal nuclease 1sye 
Engineering alternative beta-turn types in staphylococcal nuclease 1syf 
Engineering alternative beta-turn types in staphylococcal nuclease 1syg 
Engineering alternative beta-turn types in staphylococcal nuclease 1tqo 
Cryogenic crystal structure of staphylococcal nuclease variant truncated delta+phs i92e 1tr5 
Room temperature structure of staphylococcal nuclease variant truncated delta+phs i92e 1tt2 
Cryogenic crystal structure of staphylococcal nuclease variant truncated delta+phs i92k 1u9r 
Crystal structure of staphylococcal nuclease mutant v66e/p117g/h124l/s128a at room temperature 2enb 
Crystal structures of the binary ca2+ and pdtp complexes and the ternary complex of the asp 21->glu mutant of staphylococcal nuclease. implications for catalysis and ligand binding 2exz 
Crystal structure of staphylococcal nuclease mutant t22c 2ey1 
Crystal structure of staphylococcal nuclease mutant t22v 2ey2 
Crystal structure of staphylococcal nuclease mutant t41c 2ey5 
Crystal structure of staphylococcal nuclease mutant t41s 2ey6 
Crystal structure of staphylococcal nuclease mutant t41v 2eyf 
Crystal structure of staphylococcal nuclease mutant t44v 2eyh 
Crystal structure of staphylococcal nuclease mutant t62s 2eyj 
Crystal structure of staphylococcal nuclease mutant t62v 2eyl 
Crystal structure of staphylococcal nuclease mutant t82s 2eym 
Crystal structure of staphylococcal nuclease mutant t120c 2eyo 
Crystal structure of staphylococcal nuclease mutant t120s 2eyp 
Crystal structure of staphylococcal nuclease mutant t120v 2f0d 
Crystal structure of staphylococcal nuclease mutant i92v 2f0e 
Crystal structure of staphylococcal nuclease mutant v23l 2f0f 
Crystal structure of staphylococcal nuclease mutant l25i 2f0g 
Crystal structure of staphylococcal nuclease mutant v66i 2f0h 
Crystal structure of staphylococcal nuclease mutant v66l 2f0i 
Crystal structure of staphylococcal nuclease mutant i72l 2f0j 
Crystal structure of staphylococcal nuclease mutant i72v 2f0k 
Crystal structure of staphylococcal nuclease mutant v23i/l25i 2f0l 
Crystal structure of staphylococcal nuclease mutant v23l/i72l 2f0m 
Crystal structure of staphylococcal nuclease mutant v23l/i72v 2f0n 
Crystal structure of staphylococcal nuclease mutant l25i/i72l 2f0o 
Crystal structure of staphylococcal nuclease mutant v66i/i72v 2f0p 
Crystal structure of staphylococcal nuclease mutant v66i/v99i 2f0q 
Crystal structure of staphylococcal nuclease mutant v66l/i92l 2f0s 
Crystal structure of staphylococcal nuclease mutant v66l/i92v 2f0t 
Crystal structure of staphylococcal nuclease mutant v66l/v99i 2f0u 
Crystal structure of staphylococcal nuclease mutant v23i/l25i/i72v 2f0v 
Crystal structure of staphylococcal nuclease mutant v23l/v66l/i72l 2f0w 
Crystal structure of staphylococcal nuclease mutant v23i/l25i/v66l/i72l 2f3v 
Solution structure of 1-110 fragment of staphylococcal nuclease with v66w mutation 2f3w 
Solution structure of 1-110 fragment of staphylococcal nuclease in 2m tmao 2khs 
Solution structure of snase121:snase(111-143) complex 2nuc 
Staphlococcal nuclease, ethane thiol disulfide to v23c variant 2oeo 
Cryogenic crystal structure of staphylococcal nuclease variant truncated delta+phs i92d 2of1 
Cryogenic crystal structure of the staphylococcal nuclease variant truncated delta+phs i92w 2oxp 
Crystal structure of staphylococcal nuclease mutant v66d/p117g/h124l/s128a 2pqe 
Solution structure of proline-free mutant of staphylococcal nuclease 2pw5 
Crystal structure of staphylococcal nuclease variant v66y/p117g/h124l/s128a at room temperature 2pw7 
Crystal structure of staphylococcal nuclease variant v66y/p117g/h124l/s128a at 100k 2pyk 
Crystal structure of staphylococcal nuclease variant v66q/p117g/h124l/s128a at room temperature 2pzt 
Crystal structure of staphylococcal nuclease variant v66q/p117g/h124l/s128a at 100 k 2pzu 
Crystal structure of staphylococcal nuclease variant v66n/p117g/h124l/s128a at cryogenic temperature 2pzw 
Crystal structure of staphylococcal nuclease variant v66n/p117g/h124l/s128a at room temperature 2qdb 
Crystal structure of staphylococcal nuclease variant e75q/d21n/t33v/t41i/s59a/p117g/s128a at 100 k 2rbm 
Crystal structure of staphylococcal nuclease variant delta+phs i72k at cryogenic temperature 2rdf 
Crystal structure of staphyloccocal nuclease viagan/e75a variant at cryogenic temperature 2rks 
Crystal structure of staphylococcal nuclease variant phs l38k at cryogenic temperature 2snm 
In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core 2sns 
Staphylococcal nuclease. proposed mechanism of action based on structure of enzyme-thymidine 3(prime),5(prime)- biphosphate-calcium ion complex at 1.5-angstroms resolution 2sob 
Sn-ob, ob-fold sub-domain of staphylococcal nuclease, nmr, structures 2wac 
Extended tudor domain of drosophila melanogaster tudor-sn ( p100) 3bdc 
Crystal structure of staphylococcal nuclease variant delta+phs at cryogenic temperature 3bdl 
Crystal structure of a truncated human tudor-sn 3c1e 
Crystal structure of staphylococcal nuclease variant delta+phs l125k at cryogenic temperature 3c1f 
Crystal structure of staphylococcal nuclease variant delta+phs v104k at cryogenic temperature 3d4d 
Crystal structure of staphylococcal nuclease variant delta+phs y91e at cryogenic temperature 3d4w 
Crystal structure of staphylococcal nuclease variant delta+phs a109r at cryogenic temperature 3d6c 
Crystal structure of staphylococcal nuclease variant phs l38e at cryogenic temperature 3d8g 
Crystal structure of staphylococcal nuclease variant delta+phs i72r at cryogenic temperature 3dhq 
Crystal structure of staphylococcal nuclease variant delta+phs a90r at cryogenic temperature 3dmu 
Crystal structure of staphylococcal nuclease variant phs t62k at cryogenic temperature 3e5s 
Crystal structure of staphylococcal nuclease variant delta+phs l103k at cryogenic temperature 3eji 
Crystal structure of staphylococcal nuclease variant delta+phs l36k at cryogenic temperature 3ero 
Crystal structure of staphylococcal nuclease variant delta+phs i72e at cryogenic temperature 3erq 
Crystal structure of staphylococcal nuclease variant l25k at cryogenic temperature 3evq 
Crystal structure of staphylococcal nuclease variant delta+phs l25e at cryogenic temperature 3nuc 
Staphlococcal nuclease, 1-n-propane thiol disulfide to v23c variant 5nuc 
Staphylococcal nuclease, 1-n-pentane thiol disulfide to v23c variant - Links (links to other resources describing this domain)
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PFAM SNase INTERPRO IPR006021