SMART accession number:SM00339
Description: FORKHEAD, also known as a "winged helix"
Interpro abstract (IPR001766):

The fork head domain is a conserved DNA-binding domain (also known as a "winged helix") of about 100 amino-acid residues.

Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [(PUBMED:2566386)]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [(PUBMED:2566386), (PUBMED:8332212), (PUBMED:1356269)].

The fork head domain binds B-DNA as a monomer [(PUBMED:8332212)], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [(PUBMED:1356269)].

GO process:regulation of transcription, DNA-templated (GO:0006355)
GO function:DNA binding transcription factor activity (GO:0003700), sequence-specific DNA binding (GO:0043565)
Family alignment:
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There are 22315 FH domains in 22242 proteins in SMART's nrdb database.

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