SMART: HOLI domain annotation

HOLI Ligand binding domain of hormone receptors

SMART accession number:	SM00430
Description:
Interpro abstract (IPR000536):	Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. Nuclear hormone receptors consist of a highly conserved DNA-binding domain that recognises specific sequences (IPR001628), connected via a linker region to a C-terminal ligand-binding domain. In addition, certain nuclear hormone receptors have an N-terminal modulatory domain (IPR001292). The ligand-binding domain acts in response to ligand binding, which caused a conformational change in the receptor to induce a response, thereby acting as a molecular switch to turn on transcriptional activity [(PUBMED:14973393)]. For example, after binding of the glucocorticoid receptor to the corticosteroid ligand, the receptor is induced to perform functions ranging from nuclear translocation, oligomerisation, cofactor/kinase/transcription factor association, and DNA binding [(PUBMED:15193451)]. The ligand-binding domain is a flexible unit, where the binding of a ligand stabilises its conformation, which in turn favours coactivator binding to modify receptor activity [(PUBMED:15661830)]; the coactivator can bind to the activator function 2 (AF2) site at the C-terminal end of the ligand-binding domain [(PUBMED:15728727)]. The binding of different ligands can alter the conformation of the ligand-binding domain, which ultimately affects the DNA-binding specificity of the DNA-binding domain. In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components. This entry represents the C-terminal ligand-binding domain.
GO process:	steroid hormone mediated signaling pathway (GO:0043401), regulation of transcription, DNA-dependent (GO:0006355)
GO component:	nucleus (GO:0005634)
GO function:	steroid hormone receptor activity (GO:0003707), sequence-specific DNA binding transcription factor activity (GO:0003700)
Family alignment:	View or

There are 3692 HOLI domains in 3684 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with HOLI domain is also avaliable.

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Go to specific node: Anopheles gambiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes
Cellular role (predicted cellular role)
Binding / catalysis: hormones
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Gronemeyer H, Laudet V
- Transcription factors 3: nuclear receptors.
- Protein Profile. 1995; 2: 1173-308
- Evans RM
- The steroid and thyroid hormone receptor superfamily.
- Science. 1988; 240: 889-95
- Display abstract
- Analyses of steroid receptors are important for understanding molecular details of transcriptional control, as well as providing insight as to how an individual transacting factor contributes to cell identity and function. These studies have led to the identification of a superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid. Although animals employ complex and often distinct ways to control their physiology and development, the discovery of receptor-related molecules in a wide range of species suggests that mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
Disease (disease genes where sequence variants are found in this domain)

Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

Protein	Disease
Hepatocyte nuclear factor 4-alpha (P41235) (SMART)	OMIM:600281: MODY, type 1 OMIM:125850: {Diabetes mellitus, noninsulin-dependent} OMIM:125853:
Peroxisome proliferator-activated receptor gamma (P37231) (SMART)	OMIM:601487: Obesity, severe OMIM:601665: [Obesity, protection against] ; Diabetes mellitus, insulin-resistant, with acanthosis nigricans and hypertension OMIM:604367:
Androgen receptor (P10275) (SMART)	OMIM:313700: Androgen insensitivity, several forms ; Spinal and bulbar muscular atrophy of Kennedy OMIM:313200: Prostate cancer ; Perineal hypospadias ; Breast cancer, male, with Reifenstein syndrome
Photoreceptor-specific nuclear receptor (Q9Y5X4) (SMART)	OMIM:604485: Enhanced S-cone syndrome OMIM:268100: Retinitis pigmentosa, late onset OMIM:268000:
UNKNOWN (SMART)	OMIM:190160: Thyroid hormone resistance OMIM:274300: OMIM:188570:
Estrogen receptor (P03372) (SMART)	OMIM:133430: Breast cancer ; Estrogen resistance
Glucocorticoid receptor (P04150) (SMART)	OMIM:138040: Cortisol resistance
UNKNOWN (SMART)	OMIM:300200: Adrenal hypoplasia, congenital, with hypogonadotropic hypogonadism ; Dosage-sensitive sex reversal OMIM:300018:
Vitamin D3 receptor (P11473) (SMART)	OMIM:601769: Rickets, vitamin D-resistant OMIM:277440: ?Osteoporosis, involutional

3D Structures of HOLI domains in PDB

PDB code	Main view	Title
1a28		Hormone-bound human progesterone receptor ligand-binding domain
1a52		Estrogen receptor alpha ligand-binding domain complexed to estradiol
1bsx		Structure and specificity of nuclear receptor-coactivator interactions
1db1		Crystal structure of the nuclear receptor for vitamin d complexed to vitamin d
1dkf		Crystal structure of a heterodimeric complex of rar and rxr ligand-binding domains
1e3g		Human androgen receptor ligand binding in complex with the ligand metribolone (r1881)
1e3k		Human progesteron receptor ligand binding domain in complex with the ligand metribolone (r1881)
1ere		Human estrogen receptor ligand-binding domain in complex with 17beta-estradiol
1err		Human estrogen receptor ligand-binding domain in complex with raloxifene
1exa		Enantiomer discrimination illustrated by crystal structures of the human retinoic acid receptor hrargamma ligand binding domain: the complex with the active r-enantiomer bms270394.
1exx		Enantiomer discrimination illustrated by crystal structures of the human retinoic acid receptor hrargamma ligand binding domain: the complex with the inactive s-enantiomer bms270395.
1fby		Crystal structure of the human rxr alpha ligand binding domain bound to 9-cis retinoic acid
1fcx		Isotype selectivity of the human retinoic acid nuclear receptor hrar: the complex with the rargamma-selective retinoid bms184394
1fcy		Isotype selectivity of the human retinoic acid nuclear receptor hrar: the complex with the rarbeta/gamma- selective retinoid cd564
1fcz		Isotype selectivity of the human retinoic acid nuclear receptor hrar: the complex with the panagonist retinoid bms181156
1fd0		Isotype selectivity of the human retinoic acid nuclear receptor hrar: the complex with the rargamma-selective retinoid sr11254
1fm6		The 2.1 angstrom resolution crystal structure of the heterodimer of the human rxralpha and ppargamma ligand binding domains respectively bound with 9-cis retinoic acid and rosiglitazone and co-activator peptides.
1fm9		The 2.1 angstrom resolution crystal structure of the heterodimer of the human rxralpha and ppargamma ligand binding domains respectively bound with 9-cis retinoic acid and gi262570 and co-activator peptides.
1g1u		The 2.5 angstrom resolution crystal structure of the rxralpha ligand binding domain in tetramer in the absence of ligand
1g2n		Crystal structure of the ligand binding domain of the ultraspiracle protein usp, the ortholog of rxrs in insects
1g50		Crystal structure of a wild type her alpha lbd at 2.9 angstrom resolution
1g5y		The 2.0 angstrom resolution crystal structure of the rxralpha ligand binding domain tetramer in the presence of a non-activating retinoic acid isomer.
1gs4		Structural basis for the glucocorticoid response in a mutant human androgen receptor (arccr) derived from an androgen-independent prostate cancer
1gwq		Human oestrogen receptor alpha ligand-binding domain in complex with raloxifene core and tif2 nrbox2 peptide
1gwr		Human oestrogen receptor alpha ligand-binding domain in complex with 17beta-oestradiol and tif2 nrbox3 peptide
1gwx		Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
1h9u		The structure of the human retinoid-x-receptor beta ligand binding domain in complex with the specific synthetic agonist lg100268
1hg4		Ultraspiracle ligand binding domain from drosophila melanogaster
1hj1		Rat oestrogen receptor beta ligand-binding domain in complex with pure antioestrogen ici164,384
1i37		Crystal structure of the rat androgen receptor ligand binding domain complex with dihydrotestosterone
1i38		Crystal structure of the rat androgen receptor ligand binding domain t877a mutant complex with dihydrotestosterone
1i7g		Crystal structure of the ligand binding domain from human ppar-alpha in complex with the agonist az 242
1i7i		Crystal structure of the ligand binding domain of human ppar-gamma in complex with the agonist az 242
1ie8		Crystal structure of the nuclear receptor for vitamin d ligand binding domain bound to kh1060
1ie9		Crystal structure of the nuclear receptor for vitamin d ligand binding domain bound to mc1288
1ilg		Crystal structure of apo human pregnane x receptor ligand binding domain
1ilh		Crystal structure of human pregnane x receptor ligand binding domain bound to sr12813
1k4w		X-ray structure of the orphan nuclear receptor ror beta ligand-binding domain in the active conformation
1k74		The 2.3 angstrom resolution crystal structure of the heterodimer of the human ppargamma and rxralpha ligand binding domains respectively bound with gw409544 and 9-cis retinoic acid and co-activator peptides.
1k7l		The 2.5 angstrom resolution crystal structure of the human pparalpha ligand binding domain bound with gw409544 and a co-activator peptide.
1kkq		Crystal structure of the human ppar-alpha ligand-binding domain in complex with an antagonist gw6471 and a smrt corepressor motif
1knu		Ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with a synthetic agonist
1kv6		X-ray structure of the orphan nuclear receptor err3 ligand- binding domain in the constitutively active conformation
1l2i		Human estrogen receptor alpha ligand-binding domain in complex with (r,r)-5,11-cis-diethyl-5,6,11,12- tetrahydrochrysene-2,8-diol and a glucocorticoid receptor interacting protein 1 nr box ii peptide
1l2j		Human estrogen receptor beta ligand-binding domain in complex with (r,r)-5,11-cis-diethyl-5,6,11,12- tetrahydrochrysene-2,8-diol
1lbd		Ligand-binding domain of the human nuclear receptor rxr- alpha
1lv2		Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids
1m13		Crystal structure of the human pregane x receptor ligand binding domain in complex with hyperforin, a constituent of st. john's wort
1m2z		Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a tif2 coactivator motif
1m7w		Hnf4a ligand binding domain with bound fatty acid
1mv9		Crystal structure of the human rxr alpha ligand binding domain bound to the eicosanoid dha (docosa hexaenoic acid) and a coactivator peptide
1mvc		Crystal structure of the human rxr alpha ligand binding domain bound to the synthetic agonist compound bms 649 and a coactivator peptide
1mzn		Crystal structure at 1.9 angstroems resolution of the homodimer of human rxr alpha ligand binding domain bound to the synthetic agonist compound bms 649 and a coactivator peptide
1n46		Crystal structure of human tr beta ligand-binding domain complexed with a potent subtype-selective thyromimetic
1n4h		Characterization of ligands for the orphan nuclear receptor rorbeta
1n83		Crystal structure of the complex between the orphan nuclear hormone receptor ror(alpha)-lbd and cholesterol
1nav		Thyroid receptor alpha in complex with an agonist selective for thyroid receptor beta1
1nax		Thyroid receptor beta1 in complex with a beta-selective ligand
1nde		Estrogen receptor beta with selective triazine modulator
1nhz		Crystal structure of the antagonist form of glucocorticoid receptor
1nq0		Tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the nterminal lbd
1nq1		Tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the nterminal lbd
1nq2		Two rth mutants with impaired hormone binding
1nq7		Characterization of ligands for the orphan nuclear receptor rorbeta
1nrl		Crystal structure of the human pxr-lbd in complex with an src-1 coactivator peptide and sr12813
1nuo		Two rth mutants with impaired hormone binding
1nyx		Ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with an agonist
1osh		A chemical, genetic, and structural analysis of the nuclear bile acid receptor fxr
1osv		Structural basis for bile acid binding and activation of the nuclear receptor fxr
1ot7		Structural basis for 3-deoxy-cdca binding and activation of fxr
1ovl		Crystal structure of nurr1 lbd
1p8d		X-ray crystal structure of lxr ligand binding domain with 24(s),25-epoxycholesterol
1p93		Crystal structure of the agonist form of glucocorticoid receptor
1pcg		Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions
1pdu		Ligand-binding domain of drosophila orphan nuclear receptor dhr38
1pk5		Crystal structure of the orphan nuclear receptor lrh-1
1pq6		Human lxr beta hormone receptor / gw3965 complex
1pq9		Human lxr beta hormone receptor complexed with t0901317 complex
1pqc		Human lxr beta hormone receptor complexed with t0901317
1prg		Ligand binding domain of the human peroxisome proliferator activated receptor gamma
1pzl		Crystal structure of hnf4a lbd in complex with the ligand and the coactivator src-1 peptide
1q4x		Crystal structure of human thyroid hormone receptor beta lbd in complex with specific agonist gc-24
1qkm		Human oestrogen receptor beta ligand-binding domain in complex with partial agonist genistein
1qkn		Rat oestrogen receptor beta ligand-binding domain in complex with antagonist raloxifene
1qkt		Mutant estrogen nuclear receptor ligand binding domain complexed with estradiol
1qku		Wild type estrogen nuclear receptor ligand binding domain complexed with estradiol
1r1k		Crystal structure of the ligand-binding domains of the heterodimer ecr/usp bound to ponasterone a
1r20		Crystal structure of the ligand-binding domains of the heterodimer ecr/usp bound to the synthetic agonist byi06830
1r5k		Human estrogen receptor alpha ligand-binding domain in complex with gw5638
1r6g		Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound
1rdt		Crystal structure of a new rexinoid bound to the rxralpha ligand binding doamin in the rxralpha/ppargamma heterodimer
1rjk		Crystal structure of the rat vitamin d receptor ligand binding domain complexed with 2md and a synthetic peptide containing the nr2 box of drip 205
1rk3		Crystal structure of the rat vitamin d receptor ligand binding domain complexed with 1,25-dihydroxyvitamin d3 and a synthetic peptide containing the nr2 box of drip 205
1rkg		Crystal structure of the rat vitamin d receptor ligand binding domain complexed with 2mbisp and a synthetic peptide containing the nr2 box of drip 205
1rkh		Crystal structure of the rat vitamin d receptor ligand binding domain complexed with 2am20r and a synthetic peptide containing the nr2 box of drip 205
1s0x		Crystal structure of the human roralpha ligand binding domain in complex with cholesterol sulfate at 2.2a
1s0z		Crystal structure of the vdr lbd complexed to seocalcitol.
1s19		Crystal structure of vdr ligand binding domain complexed to calcipotriol.
1s9p		Crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with diethylstilbestrol
1s9q		Crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4- hydroxytamoxifen
1sj0		Human estrogen receptor alpha ligand-binding domain in complex with the antagonist ligand 4-d
1skx		Structural disorder in the complex of human pxr and the macrolide antibiotic rifampicin
1sqn		Progesterone receptor ligand binding domain with bound norethindrone
1sr7		Progesterone receptor hormone binding domain with bound mometasone furoate
1t5z		Crystal structure of the androgen receptor ligand binding domain (lbd) with dht and a peptide derived from its physiological coactivator ara70
1t63		Crystal structure of the androgen receptor ligand binding domain with dht and a peptide derived from its physiological coactivator grip1 nr box3
1t65		Crystal structure of the androgen receptor ligand binding domain with dht and a peptide derived form its physiological coactivator grip1 nr box 2 bound in a non- helical conformation
1t73		Crystal structure of the androgen receptor ligand binding domain in complex with a fxxff motif
1t74		Crystal structure of the androgen receptor ligand binding domain in complex with a wxxlf motif
1t76		Crystal structure of the androgen receptor ligand binding domain in complex with a wxxvw motif
1t79		Crystal structure of the androgen receptor ligand binding domain in complex with a fxxlw motif
1t7f		Crystal structure of the androgen receptor ligand binding domain in complex with a lxxll motif
1t7m		Crystal structure of the androgen receptor ligand binding domain in complex with a fxxyf motif
1t7r		Crystal structure of the androgen receptor ligand binding domain in complex with a fxxlf motif
1t7t		Crystal structure of the androgen receptor ligand binding domain in complex with 5-alpha dihydrotestosterone
1tfc		Crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with a steroid receptor coactivator-1 peptide
1txi		Crystal structure of the vdr ligand binding domain complexed to tx522
1u3q		Crystal structure of estrogen receptor beta complexed with cl-272
1u3r		Crystal structure of estrogen receptor beta complexed with way-338
1u3s		Crystal structure of estrogen receptor beta complexed with way-797
1u9e		Crystal structure of estrogen receptor beta complexed with way-397
1uhl		Crystal structure of the lxralfa-rxrbeta lbd heterodimer
1uom		The structure of estrogen receptor in complex with a selective and potent tetrahydroisochiolin ligand.
1upv		Crystal structure of the human liver x receptor beta ligand binding domain in complex with a synthetic agonist
1upw		Crystal structure of the human liver x receptor beta ligand binding domain in complex with a synthetic agonist
1vjb		Crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4- hydroxytamoxifen
1wm0		Ppargamma in complex with a 2-baba compound
1x76		Crystal structure of estrogen receptor beta complexed with way-697
1x78		Crystal structure of estrogen receptor beta complexed with way-244
1x7b		Crystal structure of estrogen receptor beta complexed with erb-041
1x7e		Crystal structure of estrogen receptor alpha complexed with way-244
1x7j		Crystal structure of estrogen receptor beta complexed with genistein
1x7r		Crystal structure of estrogen receptor alpha complexed with genistein
1xap		Structure of the ligand binding domain of the retinoic acid receptor beta
1xb7		X-ray structure of erralpha lbd in complex with a pgc- 1alpha peptide at 2.5a resolution
1xdk		Crystal structure of the rarbeta/rxralpha ligand binding domain heterodimer in complex with 9-cis retinoic acid and a fragment of the trap220 coactivator
1xiu		Crystal structure of the agonist-bound ligand-binding domain of biomphalaria glabrata rxr
1xj7		Complex androgen receptor lbd and rac3 peptide
1xls		Crystal structure of the mouse car/rxr lbd heterodimer bound to tcpobop and 9cra and a tif2 peptide containg the third lxxll motifs
1xnn		Crystal structure of the rat androgen receptor ligand binding domain t877a mutant complex with (3a-alpha-,4- alpha 7-alpha-,7a-alpha-)-3a,4,7,7a-tetrahydro-2-(4-nitro- 1-naphthalenyl)-4,7-ethano-1h-isoindole-1,3(2h)-dione.
1xnx		Crystal structure of constitutive androstane receptor
1xow		Crystal structure of the human androgen receptor ligand binding domain bound with an androgen receptor nh2- terminal peptide, ar20-30, and r1881
1xp1		Human estrogen receptor alpha ligand-binding domain in complex with compound 15
1xp6		Human estrogen receptor alpha ligand-binding domain in complex with compound 16
1xp9		Human estrogen receptor alpha ligand-binding domain in complex with compound 18
1xpc		Human estrogen receptor alpha ligand-binding domain in complex with compound 19
1xq3		Crystal structure of the human androgen receptor ligand binding domain bound with r1881
1xqc		X-ray structure of eralpha lbd bound to a tetrahydroisoquinoline serm ligand at 2.05a resolution
1xv9		Crystal structure of car/rxr heterodimer bound with src1 peptide, fatty acid, and 5b-pregnane-3,20-dione.
1xvp		Crystal structure of car/rxr heterodimer bound with src1 peptide, fatty acid and citco
1xzx		Thyroxine-thyroid hormone receptor interactions
1y0s		Crystal structure of ppar delta complexed with gw2331
1y0x		Thyroxine-thyroid hormone receptor interactions
1y9r		Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone and harboring the s810l mutation responsible for a severe form of hypertension
1ya3		Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the s810l mutation responsible for a severe form of hypertension
1yim		Human estrogen receptor alpha ligand-binding domain in complex with compound 4
1yin		Human estrogen receptor alpha ligand-binding domain in complex with compound 3f
1yje		Crystal structure of the rngfi-b ligand-binding domain
1ymt		Mouse sf-1 lbd
1yok		Crystal structure of human lrh-1 bound with tif-2 peptide and phosphatidylglycerol
1yow		Human steroidogenic factor 1 lbd with bound co-factor peptide
1yp0		Structure of the steroidogenic factor-1 ligand binding domain bound to phospholipid and a shp peptide motif
1yuc		Human nuclear receptor liver receptor homologue-1, lrh-1, bound to phospholipid and a fragment of human shp
1yy4		Crystal structure of estrogen receptor beta complexed with 1-chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol
1yye		Crystal structure of estrogen receptor beta complexed with way-202196
1z5x		Hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone a
1z95		Crystal structure of the androgen receptor ligand-binding domain w741l mutant complex with r-bicalutamide
1zaf		Crystal structure of estrogen receptor beta complexed with 3-bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one
1zdt		The crystal structure of human steroidogenic factor-1
1zdu		The crystal structure of human liver receptor homologue-1
1zeo		Crystal structure of human ppar-gamma ligand binding domain complexed with an alpha-aryloxyphenylacetic acid agonist
1zgy		Structural and biochemical basis for selective repression of the orphan nuclear receptor lrh-1 by shp
1zh7		Structural and biochemical basis for selective repression of the orphan nuclear receptor lrh-1 by shp
1zky		Human estrogen receptor alpha ligand-binding domain in complex with obcp-3m and a glucocorticoid receptor interacting protein 1 nr box ii peptide
1zuc		Progesterone receptor ligand binding domain in complex with the nonsteroidal agonist tanaproget
2a3i		Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor
2aa2		Mineralocorticoid receptor with bound aldosterone
2aa5		Mineralocorticoid receptor with bound progesterone
2aa6		Mineralocorticoid receptor s810l mutant with bound progesterone
2aa7		Mineralocorticoid receptor with bound deoxycorticosterone
2aax		Mineralocorticoid receptor double mutant with bound cortisone
2ab2		Mineralocorticoid receptor double mutant with bound spironolactone
2abi		Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone
2acl		Liver x-receptor alpha ligand binding domain with sb313987
2am9		Crystal structure of human androgen receptor ligand binding domain in complex with testosterone
2ama		Crystal structure of human androgen receptor ligand binding domain in complex with dihydrotestosterone
2amb		Crystal structure of human androgen receptor ligand binding domain in complex with tetrahydrogestrinone
2ao6		Crystal structure of the human androgen receptor ligand binding domain bound with tif2(iii) 740-753 peptide and r1881
2ath		Crystal structure of the ligand binding domain of human ppar-gamma im complex with an agonist
2awh		Human nuclear receptor-ligand complex 1
2ax6		Crystal structure of the androgen receptor ligand binding domain t877a mutant in complex with hydroxyflutamide
2ax7		Crystal structure of the androgen receptor ligand binding domain t877a mutant in complex with s-1
2ax8		Crystal structure of the androgen receptor ligand binding domain w741l mutant in complex with s-1
2ax9		Crystal structure of the androgen receptor ligand binding domain in complex with r-3
2axa		Crystal structure of the androgen receptor ligand binding domain in complex with s-1
2ayr		A serm designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats
2b1v		Human estrogen receptor alpha ligand-binding domain in complex with obcp-1m and a glucocorticoid receptor interacting protein 1 nr box ii peptide
2b1z		Human estrogen receptor alpha ligand-binding domain in complex with 17methyl-17alpha-dihydroequilenin and a glucoc interacting protein 1 nr box ii peptide
2b23		Human estrogen receptor alpha ligand-binding domain and a glucocorticoid receptor-interacting protein 1 nr box ii peptide
2b50		Human nuclear receptor-ligand complex 2
2baw		Human nuclear receptor-ligand complex 1
2bj4		Estrogen receptor alpha lbd in complex with a phage-display derived peptide antagonist
2e2r		Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with bisphenol a
2ewp		Crystal structure of estrogen related reecptor-3 (err- gamma) ligand binding domaind with tamoxifen analog gsk5182
2f4b		Crystal structure of the ligand binding domain of human ppar-gamma in complex with an agonist
2fai		Human estrogen receptor alpha ligand-binding domain in complex with obcp-2m and a glucocorticoid receptor interacting protein 1 nr box ii peptide
2fsz		A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta
2fvj		A novel anti-adipogenic partial agonist of peroxisome proliferator-activated receptor-gamma (pparg) recruits pparg-coactivator-1 alpha (pgc1a) but potentiates insulin signaling in vitro
2g0g		Structure-based drug design of a novel family of ppar partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities
2g0h		Structure-based drug design of a novel family of ppar partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities
2g44		Human estrogen receptor alpha ligand-binding domain in complex with obcp-1m-g and a glucocorticoid receptor interacting protein 1 nr box ii peptide
2g5o		Human estrogen receptor alpha ligand-binding domain in complex with 2-(but-1-enyl)-17beta-estradiol and a glucocorticoid receptor interacting protein 1 nr box ii peptide
2giu		Human estrogen receptor beta ligand-binding domain in complex with compound 45
2gl8		Human retinoic acid receptor rxr-gamma ligand-binding domain
2gp7		Estrogen related receptor-gamma ligand binding domain
2gpo		Estrogen related receptor-gamma ligand binding domain complexed with a synthetic peptide from rip140
2gpp		Estrogen related receptor-gamma ligand binding domain complexed with a rip140 peptide and synthetic ligand gsk4716
2gpu		Estrogen related receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen
2gpv		Estrogen related receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen and a smrt peptide
2gtk		Structure-based design of indole propionic acids as novel pparag co-agonists
2gwx		Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
2h77		Crystal structure of human tr alpha bound t3 in monoclinic space group
2h79		Crystal structure of human tr alpha bound t3 in orthorhombic space group
2ham		Crystal structure of vdr lbd complexed to 2alpha-propyl- calcitriol
2har		Crystal structure of vdr lbd in complex with 2 alpha-(3- hydroxy-1-propoxy) calcitriol
2has		Crystal structure of vdr lbd in complex with 2alpha-(1- propoxy) calcitriol
2hb7		Crystal structure of vdr lbd in complex with 2alpha(3- hydroxy-1-propyl) calcitriol
2hb8		Crystal structure of vdr lbd in complex with 2alpha-methyl calcitriol
2hbh		Crystal structure of vitamin d nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and src-1 peptide
2hc4		Crystal structure of the lbd of vdr of danio rerio in complex with calcitriol
2hcd		Crystal structure of the ligand binding domain of the vitamin d nuclear receptor in complex with gemini and a coactivator peptide
2hfp		Crystal structure of ppar gamma with n-sulfonyl-2-indole carboxamide ligands
2hvc		The crystal structure of ligand-binding domain (lbd) of human androgen receptor in complex with a selective modulator lgd2226
2hwq		Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists
2hwr		Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists
2i0g		Benzopyrans are selective estrogen receptor beta agonists (serbas) with novel activity in models of benign prostatic hyperplasia
2i0j		Benzopyrans are selective estrogen receptor beta agonists (serbas) with novel activity in models of benign prostatic hyperplasia
2i4j		Crystal structure of the complex between ppargamma and the agonist lt160 (ureidofibrate derivative)
2i4p		Crystal structure of the complex between ppargamma and the partial agonist lt127 (ureidofibrate derivative). structure obtained from crystals of the apo-form soaked for 30 days.
2i4z		Crystal structure of the complex between ppargamma and the partial agonist lt127 (ureidofibrate derivative). this structure has been obtained from crystals soaked for 6 hours.
2ihq		Crystal structure of the rat androgen receptor ligand binding domian complex with an n-aryl- hydroxybicyclohydantoin
2iog		Human estrogen receptor alpha ligand-binding domain in complex with compound 11f
2iok		Human estrogen receptor alpha ligand-binding domain in complex with compound 1d
2iz2		Crystal structure of the ligand binding domain of fushi tarazu factor 1 from drosophila melanogaster
2j14		3,4,5-trisubstituted isoxazoles as novel ppardelta agonists: part2
2j4a		Human thyroid hormone receptor beta ligand binding domain in complex with kb131084
2j7x		Structure of estradiol-bound estrogen receptor beta lbd in complex with lxxll motif from ncoa5
2j7y		Structure of 17-epiestriol-bound estrogen receptor beta lbd in complex with lxxll motif from ncoa5
2jf9		Estrogen receptor alpha lbd in complex with a tamoxifen- specific peptide antagonist
2jfa		Estrogen receptor alpha lbd in complex with an affinity- selected corepressor peptide
2jj3		Estrogen receptor beta ligand binding domain in complex with a benzopyran agonist
2lbd		Ligand-binding domain of the human retinoic acid receptor gamma bound to all-trans retinoic acid
2npa		The crystal structure of the human pparaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid
2nv7		Crystal structure of estrogen receptor beta complexed with way-555
2nw4		Crystal structure of the rat androgen receptor ligand binding domain complex with bms-564929
2nxx		Crystal structure of the ligand-binding domains of the t.castaneum (coleoptera) heterodimer ecrusp bound to ponasterone a
2o4j		Crystal structure of rat vitamin d receptor ligand binding domain complexed with vitiii 17-20z and the nr2 box of drip 205
2o4r		Crystal structure of rat vitamin d receptor ligand binding domain complexed with vitiii 17-20e and the nr2 box of drip 205
2o9i		Crystal structure of the human pregnane x receptor lbd in complex with an src-1 coactivator peptide and t0901317
2oax		Crystal structure of the s810l mutant mineralocorticoid receptor associated with sc9420
2ocf		Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the e2#23 fn3 monobody
2om9		Ajulemic acid, a synthetic cannabinoid bound to ppar gamma
2ouz		Crystal structure of estrogen receptor alpha-lasofoxifene complex
2ovh		Progesterone receptor with bound asoprisnil and a peptide from the co-repressor smrt
2ovm		Progesterone receptor with bound asoprisnil and a peptide from the co-repressor ncor
2oz7		Crystal structure of the human androgen receptor t877a mutant ligand-binding domain with cyproterone acetate
2p15		Crystal structure of the er alpha ligand binding domain with the agonist ortho-trifluoromethylphenylvinyl estradiol
2p1t		Crystal structure of the ligand binding domain of the retinoid x receptor alpha in complex with 3-(2'-methoxy)- tetrahydronaphtyl cinnamic acid and a fragment of the coactivator tif-2
2p1u		Crystal structure of the ligand binding domain of the retinoid x receptor alpha in complex with 3-(2'-ethoxy)- tetrahydronaphtyl cinnamic acid and a fragment of the coactivator tif-2
2p1v		Crystal structure of the ligand binding domain of the retinoid x receptor alpha in complex with 3-(2'-propoxy)- tetrahydronaphtyl cinnamic acid and a fragment of the coactivator tif-2
2p4y		Crystal structure of human ppar-gamma-ligand binding domain complexed with an indole-based modulator
2p54		A crystal structure of ppar alpha bound with src1 peptide and gw735
2p7a		Crystal structure of estrogen related receptor g in complex with 3-methyl phenol
2p7g		X-ray structure of estrogen related receptor g in complex with bisphenol a.
2p7z		Estrogen related receptor gamma in complex with 4-hydroxy- tamoxifen
2pin		Thyroid receptor beta in complex with inhibitor
2pio		Androgen receptor lbd with small molecule
2pip		Androgen receptor lbd with small molecule
2piq		Androgen receptor lbd with small molecule
2pir		Androgen receptor lbd with small molecule
2pit		Androgen receptor lbd with small molecule
2piu		Androgen receptor lbd with small molecule
2piv		Androgen receptor with small molecule
2piw		Androgen receptor with small molecule
2pix		Ar lbd with small molecule
2pjl		Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism
2pkl		Androgen receptor lbd with small molecule
2pnu		Crystal structure of human androgen receptor ligand-binding domain in complex with em-5744
2pob		Ppargamma ligand binding domain complexed with a farglitazar analogue gw4709
2pog		Benzopyrans as selective estrogen receptor b agonists (serbas). part 2: structure activity relationship studies on the benzopyran scaffold.
2prg		Ligand-binding domain of the human peroxisome proliferator activated receptor gamma
2q1h		Ancestral corticoid receptor in complex with aldosterone
2q1v		Ancestral corticoid receptor in complex with cortisol
2q3y		Ancestral corticiod receptor in complex with doc
2q59		Crystal structure of ppargamma lbd bound to full agonist mrl20
2q5g		Ligand binding domain of ppar delta receptor in complex with a partial agonist
2q5p		Crystal structure of ppargamma bound to partial agonist mrl24
2q5s		Crystal structure of ppargamma bound to partial agonist ntzdpa
2q60		Crystal structure of the ligand binding domain of polyandrocarpa misakiensis rxr in tetramer in absence of ligand
2q61		Crystal structure of ppargamma ligand binding domain bound to partial agonist sr145
2q6j		Crystal structure of estrogen receptor alpha complexed to a b-n substituted ligand
2q6r		Crystal structure of ppar gamma complexed with partial agonist sf147
2q6s		2.4 angstrom crystal structure of ppar gamma complexed to bvt.13 without co-activator peptides
2q70		Estrogen receptor alpha ligand-binding domain complxed to a benzopyran ligand
2q7i		The wild type androgen receptor ligand binding domain bound with testosterone and an ar 20-30 peptide
2q7j		The wild type androgen receptor ligand binding domain bound with testosterone and a tif2 box 3 coactivator peptide 740-
2q7k		The androgen receptor prostate cancer mutant h874y ligand binding domain bound with testosterone and an ar 20-30 peptide
2q7l		The androgen receptor prostate cancer mutant h874y ligand binding domain bound with testosterone and a tif2 box3 coactivator peptide 740-753
2q8s		X-ray crystal structure of the nuclear hormone receptor ppar-gamma in a complex with a ppar gamma/alpha dual agonist
2qa6		Crystal structure of estrogen receptor alpha mutant 537s complexed with 4-(6-hydroxy-1h-indazol-3-yl)benzene-1,3- diol
2qa8		Crystal structure of the estrogen receptor alpha ligand binding domain mutant 537s complexed with genistein
2qab		Crystal structure of estrogen receptor alpha ligand binding domain mutant 537s complexed with an ethyl indazole compound
2qe4		Estrogen receptor alpha ligand-binding domain in complex with a benzopyran agonist
2qgt		Crystal structure of the estrogen receptor alpha ligand binding domain complexed to an ether estradiol compound
2qgw		Crystal structure of the estrogen receptor alpha ligand binding domain complexed with a chloro-indazole compound
2qh6		Crystal structure of the estrogen receptor alpha ligand binding domain complexed with an oxabicyclic diarylethylene compound
2qmv		High resolution structure of peroxisone proliferation- activated receptor gamma and characterisation of its interaction with the co-activator transcriptional intermediary factor 2
2qnv		Crystal structure of the pregnane x receptor bound to colupulone
2qpy		Ar lbd with small molecule
2qr9		Crystal structure of the estrogen receptor alpha ligand binding domain complexed with an oxabicyclic derivative compound
2qse		Crystal structure of the estrogen receptor alpha ligand binding domain complexed with burned meat compound 4-oh- phip
2qtu		Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand
2qw4		Human nr4a1 ligand-binding domain
2qxm		Crystal structure of the estrogen receptor alpha ligand binding domain complexed to burned meat compound phip
2qxs		Crystal structure of antagonizing mutant 536s of the estrogen receptor alpha ligand binding domain complexed to raloxifene
2qzo		Crystal structure of the estrogen receptor alpha ligand binding domain complexed with way-169916
2r40		Crystal structure of 20e bound ecr/usp
2r6w		Estrogen receptor alpha ligand-binding domain complexed to a serm
2r6y		Estrogen receptor alpha ligand-binding domain in complex with a serm
2rew		Crystal structure of pparalpha ligand binding domain with bms-631707
2v0v		Crystal structure of rev-erb beta
2v7c		Crystal structure of rev-erb beta
2vsr		Hppargamma ligand binding domain in complex with 9-(s)-hode
2vst		Hppargamma ligand binding domain in complex with 13-(s)- hode
2vv0		Hppargamma ligand binding domain in complex with dha
2vv1		Hppargamma ligand binding domain in complex with 4-hdha
2vv2		Hppargamma ligand binding domain in complex with 5-hepa
2vv3		Hppargamma ligand binding domain in complex with 4-oxodha
2vv4		Hppargamma ligand binding domain in complex with 6-oxoote
2w8y		Ru486 bound to the progesterone receptor in a destabilized agonistic conformation
2z4b		Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand
2z4j		Crystal structure of ar lbd with shp peptide nr box 2
2zas		Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with 4-alpha-cumylphenol, a bisphenol a derivative
2zbs		Crystal structure of human estrogen-related receptor gamma ligand binding domain apo form
2zfx		Crystal structure of the rat vitamin d receptor ligand binding domain complexed with yr301 and a synthetic peptide containing the nr2 box of drip 205
2zk0		Human peroxisome proliferator-activated receptor gamma ligand binding domain
2zk1		Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 15-deoxy-delta12,14- prostaglandin j2
2zk2		Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with glutathion conjugated 15-deoxy-delta12,14-prostaglandin j2
2zk3		Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 8-oxo- eicosatetraenoic acid
2zk4		Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 15-oxo- eicosatetraenoic acid
2zk5		Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with nitro-233
2zk6		Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with c8-bodipy
2zkc		Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with bisphenol z
2zl9		2-substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27- dimethyl-19-norvitamin d3 analogs: synthesis, biological evaluation and crystal structure
2zla		2-substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27- dimethyl-19-norvitamin d3 analogs: synthesis, biological evaluation and crystal structure
2zlc		2-substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27- dimethyl-19-norvitamin d3 analogs: synthesis, biological evaluation and crystal structure
2zmh		Crystal structure of rat vitamin d receptor bound to adamantyl vitamin d analogs: structural basis for vitamin d receptor antagonism and/or partial agonism
2zmi		Crystal structure of rat vitamin d receptor bound to adamantyl vitamin d analogs: structural basis for vitamin d receptor antagonism and/or partial agonism
2zmj		Crystal structure of rat vitamin d receptor bound to adamantyl vitamin d analogs: structural basis for vitamin d receptor antagonism and/or partial agonism
2znn		Human pprr alpha ligand binding domain in complex with a synthetic agonist tipp703
2zno		Human pprr gamma ligand binding domain in complex with a synthetic agonist tipp703
2znp		Human pprr delta ligand binding domain in complex with a synthetic agonist tipp204
2znq		Human pprr delta ligand binding domain in complex with a synthetic agonist tipp401
2zvt		Cys285ser mutant ppargamma ligand-binding domain complexed with 15-deoxy-delta12,14-prostaglandin j2
2zxm		A new class of vitamin d receptor ligands that induce structural rearrangement of the ligand-binding pocket
2zxn		A new class of vitamin d receptor ligands that induce structural rearrangement of the ligand-binding pocket
2zxz		Crystal structure of the human rxr alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide
2zy0		Crystal structure of the human rxr alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide
3b3k		Crystal structure of the complex between ppargamma and the full agonist lt175
3b5r		Crystal structure of the androgen receptor ligand binding domain in complex with sarm c-31
3b65		Crystal structure of the androgen receptor ligand binding domain in complex with sarm s-24
3b66		Crystal structure of the androgen receptor ligand binding domain in complex with sarm s-21
3b67		Crystal structure of the androgen receptor ligand binding domain in complex with sarm c-23
3b68		Crystal structure of the androgen receptor ligand binding domain in complex with sarm s-4
3bc5		X-ray crystal structure of human ppar gamma with 2-(5-(3-(2- (5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)-2-phenyl-2h-1, 2,3-triazol-4-yl)acetic acid
3bej		Structure of human fxr in complex with mfa-1 and co- activator peptide
3bqd		Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol
3cdp		Crystal structure of ppar-gamma lbd complexed with a partial agonist, analogue of clofibric acid
3cds		Crystal structure of the complex between ppar-gamma and the agonist lt248 (clofibric acid analogue)
3cjw		Crystal structure of the human coup-tfii ligand binding domain
3cld		Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate
3cqv		Crystal structure of reverb beta in complex with heme
3cs4		Structure-based design of a superagonist ligand for the vitamin d nuclear receptor
3cs6		Structure-based design of a superagonist ligand for the vitamin d nuclear receptor
3cs8		Structural and biochemical basis for the binding selectivity of pparg to pgc-1a
3ctb		Tethered pxr-lbd/src-1p apoprotein
3cwd		Molecular recognition of nitro-fatty acids by ppar gamma
3d24		Crystal structure of ligand-binding domain of estrogen- related receptor alpha (erralpha) in complex with the peroxisome proliferators-activated receptor coactivator- 1alpha box3 peptide (pgc-1alpha)
3d57		Tr variant d355r
3d5f		Crystal structure of ppar-delta complex
3d6d		Crystal structure of the complex between ppargamma lbd and the lt175(r-enantiomer)
3d90		Crystal structure of the human progesterone receptor ligand- binding domain bound to levonorgestrel
3dct		Fxr with src1 and gw4064
3dcu		Fxr with src1 and gsk8062
3dr1		Side-chain fluorine atoms of non-steroidal vitamin d3 analogs stabilize helix 12 of vitamin d receptor
3dt3		Human estrogen receptor alpha lbd with gw368
3dy6		Ppardelta complexed with an anthranilic acid partial agonist
3dzu		Intact ppar gamma - rxr alpha nuclear receptor complex on dna bound with bvt.13, 9-cis retinoic acid and ncoa2 peptide
3dzy		Intact ppar gamma - rxr alpha nuclear receptor complex on dna bound with rosiglitazone, 9-cis retinoic acid and ncoa2 peptide
3e00		Intact ppar gamma - rxr alpha nuclear receptor complex on dna bound with gw9662, 9-cis retinoic acid and ncoa2 peptide
3e7c		Glucocorticoid receptor lbd bound to gsk866
3e94		Crystal structure of rxralpha ligand binding domain in complex with tributyltin and a coactivator fragment
3erd		Human estrogen receptor alpha ligand-binding domain in complex with diethylstilbestrol and a glucocorticoid receptor interacting protein 1 nr box ii peptide
3ert		Human estrogen receptor alpha ligand-binding domain in complex with 4-hydroxytamoxifen
3et0		Structure of ppargamma with 3-(5-methoxy-1h-indol-3-yl)- propionic acid
3et1		Structure of pparalpha with 3-[5-methoxy-1-(4-methoxy- benzenesulfonyl)-1h-indol-3-yl]-propionic acid
3et2		Structure of ppardelta with 3-[5-methoxy-1-(4-methoxy- benzenesulfonyl)-1h-indol-3-yl]-propionic acid
3et3		Structure of ppargamma with 3-[5-methoxy-1-(4-methoxy- benzenesulfonyl)-1h-indol-3-yl]-propionic acid
3eyb		Structural and functional insights into the ligand binding domain of a non-duplicated rxr from the invertebrate chordate amphioxus
3f5c		Structure of dax-1:lrh-1 complex
3f7d		Sf-1 lbd bound by phosphatidylcholine
3fal		Humanrxr alpha & mouse lxr alpha complexed with retenoic acid and gsk2186
3fc6		Hrxralpha & mlxralpha with an indole pharmacophore, sb786875
3fei		Design and biological evaluation of novel, balanced dual ppara/g agonists
3fej		Design and biological evaluation of novel, balanced dual ppara/g agonists
3fs1		Crystal structure of hnf4a lbd in complex with the ligand and the coactivator pgc-1a fragment
3fug		Crystal structure of the retinoid x receptor ligand binding domain bound to the synthetic agonist 3-[4-hydroxy-3-(3,5, 5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)- phenyl]acrylic acid
3fur		Crystal structure of pparg in complex with int131
3fxv		Identification of an n-oxide pyridine gw4064 analogue as a potent fxr agonist
3g0w		Crystal structure of the rat androgen receptor ligand binding domain complex with an n-aryl-oxazolidin 2-imine inhibitor
3g8i		Aleglitazar, a new, potent, and balanced ppar alpha/gamma agonist for the treatment of type ii diabetes
3g9e		Aleglitaar. a new. potent, and balanced dual ppara/g agonist for the treatment of type ii diabetes
3gd2		Isoxazole ligand bound to farnesoid x receptor (fxr)
3gn8		X-ray crystal structure of ancgr2 in complex with dexamethasone
3gws		Crystal structure of t3-bound thyroid hormone receptor
3gwx		Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
3gyt		Nuclear receptor daf-12 from parasitic nematode strongyloides stercoralis in complex with its physiological ligand dafachronic acid delta 4
3gyu		Nuclear receptor daf-12 from parasitic nematode strongyloides stercoralis in complex with its physiological ligand dafachronic acid delta 7
3gz9		Crystal structure of peroxisome proliferator-activated receptor delta (ppard) in complex with a full agonist
3h0a		Crystal structure of peroxisome proliferator-activated receptor gamma (pparg) and retinoic acid receptor alpha (rxra) in complex with 9-cis retinoic acid, co-activator peptide, and a partial agonist
3hc5		Fxr with src1 and gsk826
3hc6		Fxr with src1 and gsk088
3ho0		Crystal structure of the ppargamma-lbd complexed with a new aryloxy-3phenylpropanoic acid
3hod		Crystal structure of the ppargamma-lbd complexed with a new aryloxy-3phenylpropanoic acid
3hvl		Tethered pxr-lbd/src-1p complexed with sr-12813
3hzf		Structure of tr-alfa bound to selective thyromimetic gc-1 in c2 space group
3ia6		X-ray crystal structure of the nuclear hormone receptor ppar-gamma in a complex with a ppar gamma/alpha dual agonist
3imy		Structure of tr-beta bound to selective thyromimetic gc-1
3k23		Glucocorticoid receptor with bound d-prolinamide 11
3k8s		Crystal structure of pparg in complex with t2384
3lbd		Ligand-binding domain of the human retinoic acid receptor gamma bound to 9-cis retinoic acid
3prg		Ligand binding domain of human peroxisome proliferator activated receptor
4lbd		Ligand-binding domain of the human retinoic acid receptor gamma bound to the synthetic agonist bms961
4prg		Partial agonist ppar gamma cocrystal

Links (links to other resources describing this domain)
PFAM hormone_rec
INTERPRO IPR000536

PFAM	hormone_rec
INTERPRO	IPR000536