Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

• HOME
• SETUP
• FAQ
• ABOUT
• GLOSSARY
• WHAT'S NEW
• FEEDBACK

RWD

SMART accession number:	SM00591
Description:	domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
Interpro abstract (IPR006575):	The RWD eukaryotic domain is found in RING finger (IPR001841) and WD repeat (IPR001680) containing proteins and DEXDc-like helicase (IPR001410) subfamily related to the ubiquitin-conjugating enzymes domain (IPR000608).
GO function:	protein binding (GO:0005515)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 994 RWD domains in 994 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a RWD domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with RWD domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Doerks T, Copley RR, Schultz J, Ponting CP, Bork P
  • Systematic identification of novel protein domain families associated with nuclear functions.
  • Genome Res. 2002; 12: 47-56
  • Display abstract

  • A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 54.55 map00380 Tryptophan metabolism 45.45 map04120 Ubiquitin mediated proteolysis This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with RWD domain which could be assigned to a KEGG orthologous group, and not all proteins containing RWD domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of RWD domains in PDB

  PDB code	Main view	Title
  1ukx		Solution structure of the rwd domain of mouse gcn2
  2daw		Solution structure of the rwd domain of human rwd omain containing protein 2
  2dax		Solution structure of the rwd domain of human protein c21orf6
  2day		Solution structure of the rwd domain of human ring finger protein 25
  2dmf		An extended conformation of the rwd domain of human ring finger protein 25
  2ebk		Solution structure of the rwd domain of human rwd domain containing protein 3
  2ebm		Solution structure of the rwd domain of human rwd domain containing protein 1
  2yz0		Solution structure of rwd/gi domain of saccharomyces cerevisiae gcn2

• Links (links to other resources describing this domain)

• INTERPRO	IPR006575

Send comments to Ivica Letunic