TAF

TATA box binding protein associated factor
TAF
SMART accession number:SM00803
Description: TAFs (TATA box binding protein associated factors) are part of the transcription initiation factor TFIID multimeric protein complex. TFIID is composed of the TATA box binding protein (TBP) and a number of TAFs. The TAFs provide binding sites for many different transcriptional activators and co-activators that modulate transcription initiation by Pol II. TAF proteins adopt a histone-like fold.
Interpro abstract (IPR004823): The TATA box binding protein associated factor (TAF) is part of the transcription initiation factor TFIID multimeric protein complex. TFIID plays a central role in mediating promoter responses to various activators and repressors. It binds tightly to TAFII-250 and directly interacts with TAFII-40. TFIID is composed of TATA binding protein (TBP)and a number of TBP-associated factors (TAFS). TAF proteins adopt a histone-like fold.
GO process:DNA-templated transcription, initiation (GO:0006352)
GO component:nucleus (GO:0005634)
Family alignment:
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There are 550 TAF domains in 550 proteins in SMART's nrdb database.

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