Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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PKS_PP Phosphopantetheine attachment site

SMART accession number:	SM00823
Description:	Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups (PUBMED:5321311).
Interpro abstract (IPR020806):	Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups [(PUBMED:5321311)]. The amino-terminal region of the ACP proteins is well defined and consists of alpha four helices arranged in a right-handed bundle held together by interhelical hydrophobic interactions. The Asp-Ser-Leu (DSL) motif is conserved in all of the ACP sequences, and the 4'-PP prosthetic group is covalently linked via a phosphodiester bond to the serine residue. The DSL sequence is present at the amino terminus of helix II, a domain of the protein referred to as the recognition helix and which is responsible for the interaction of ACPs with the enzymes of type II fatty acid synthesis [(PUBMED:11825906)]. This entry represents the phosphopantetheine-binding domain from polyketide synthases. Polyketide synthases are large multidomain proteins involved in the synthesis of secondary metabolites [(PUBMED:15958783)].
GO function:	phosphopantetheine binding (GO:0031177)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 6851 PKS_PP domains in 2659 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a PKS_PP domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with PKS_PP domain is also avaliable.

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  Go to specific node: Caenorhabditis elegans

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 9.60 map00632 Benzoate degradation via CoA ligation 8.47 map00960 Alkaloid biosynthesis II 8.47 map00903 Limonene and pinene degradation 7.91 map00310 Lysine degradation 7.34 map00350 Tyrosine metabolism 7.34 map00564 Glycerophospholipid metabolism 7.34 map00340 Histidine metabolism 7.34 map00360 Phenylalanine metabolism 7.34 map00624 1- and 2-Methylnaphthalene degradation 7.34 map00642 Ethylbenzene degradation 6.21 map01053 Biosynthesis of siderophore group nonribosomal peptides 1.69 map00251 Glutamate metabolism 1.69 map00252 Alanine and aspartate metabolism 1.69 map00471 D-Glutamine and D-glutamate metabolism 1.13 map00281 Geraniol degradation 1.13 map00562 Inositol phosphate metabolism 1.13 map00930 Caprolactam degradation 1.13 map04920 Adipocytokine signaling pathway 1.13 map03320 PPAR signaling pathway 1.13 map00071 Fatty acid metabolism 1.13 map00640 Propanoate metabolism 0.56 map00300 Lysine biosynthesis 0.56 map00130 Ubiquinone biosynthesis 0.56 map00780 Biotin metabolism 0.56 map00061 Fatty acid biosynthesis This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with PKS_PP domain which could be assigned to a KEGG orthologous group, and not all proteins containing PKS_PP domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of PKS_PP domains in PDB

  PDB code	Main view	Title
  2ju1		Solution structure of acyl carrier protein domain from module 2 of 6-deoxyerythronolide b synthase (debs)
  2ju2		Minimized mean solution structure of the acyl carrier protein domain from module 2 of 6-deoxyerythronolide b synthase (debs)

• Links (links to other resources describing this domain)

• PFAM	Phosphopantetheine attachment site
  INTERPRO	IPR020806

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