HIRAN

HIRAN
SMART accession number:SM00910
Description: The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p. HIRAN is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA phosphoesterases, in the eukaryotes (PUBMED:16627993). It has been predicted that this protein functions as a DNA-binding domain that probably recognises features associated with damaged DNA or stalled replication forks (PUBMED:16627993)
Interpro abstract (IPR014905):

The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p. HIRAN is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA phosphoesterases, in the eukaryotes [(PUBMED:16627993)]. It has been predicted that this protein functions as a DNA-binding domain that probably recognises features associated with damaged DNA or stalled replication forks [(PUBMED:16627993)].

GO function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818), zinc ion binding (GO:0008270), nucleic acid binding (GO:0003676)
Family alignment:
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There are 232 HIRAN domains in 232 proteins in SMART's nrdb database.

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