AdoHcyase_NADS-adenosyl-L-homocysteine hydrolase, NAD binding domain
|SMART accession number:||SM00997|
|Interpro abstract (IPR015878):|
S-adenosyl-L-homocysteine hydrolase (EC 188.8.131.52) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. AdoHcyase is an ubiquitous enzyme which binds and requires NAD+ as a cofactor. AdoHcyase is a highly conserved protein [(PUBMED:1631127)] of about 430 to 470 amino acids.
This entry represents the glycine-rich region in the central part of AdoHcyase, which is thought to be involved in NAD-binding [(PUBMED:1631127)].
Click on the following links for more information.
- Evolution (species in which this domain is found)
- Cellular role (predicted cellular role)
- Literature (relevant references for this domain)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)