SMI1_KNR4SMI1 / KNR4 family
|SMART accession number:||SM00860|
|Description:||Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.|
|Interpro abstract (IPR018958):|
Saccharomyces cerevisiae protein Smi1 has a regulatory role in chitin deposition and in cell wall assembly [(PUBMED:10206705)].
KNR4 is believed to connect the PKC1-SLT2 MAPK pathway with cell proliferation. It has been shown to interact with BCK2, a gene involved in cell cycle progression in S. cerevisiae (forming a complex) to allow PKC1 to coordinate the cell cycle (cell proliferation) with cell wall integrity [(PUBMED:12185498), (PUBMED:12823808)]. KNR4 also interacts with the tyrosine-tRNA synthetase protein encoded by TYS1 and is involved in sporulation process [(PUBMED:11410349)].
Proteins containing this domain also include the animal F-box only protein 3 (FBXO3). In humans, FBXO3 is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex [(PUBMED:18809579)].
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- Evolution (species in which this domain is found)
- Cellular role (predicted cellular role)
- Literature (relevant references for this domain)
- Structure (3D structures containing this domain)
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