Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2008) Nucleic Acids Res , doi:10.1093/nar/gkn808

• HOME
• SETUP
• FAQ
• ABOUT
• GLOSSARY
• WHAT'S NEW
• FEEDBACK

SNc Staphylococcal nuclease homologues

There are 765 SNc domains in 492 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a SNc domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with SNc domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Ponting CP
  • P100, a transcriptional coactivator, is a human homologue of staphylococcal nuclease.
  • Protein Sci. 1997; 6: 459-63
  • Display abstract

  • Staphylococcus aureus nuclease (SNase) homologues, previously thought to be restricted to bacteria and archaea, are demonstrated by sequence analysis to be present also in eukaryotes. The human cellular coactivator p100 is shown to contain four repeats, each of which is a SNase homologue. Surprisingly, these repeats are unlikely to possess SNase-like activities as each lacks equivalent SNase catalytic residues, yet they may mediate p100's single-stranded DNA-binding function. Products of Corydalis sempervirens and Saccharomyces cerevisiae open reading frames are predicted to adopt the same fold and possess similar functions as SNase. Five additional hypothetical proteins of bacterial origin are also predicted to be active SNase-like nucleases, including one that appears to be C-terminally truncated in a manner analogous to an engineered active SNase variant. Conservation of Asp-19 and Asp-83 among these homologues suggests a re-evaluation of the roles of these residues in Ca(2+)-binding and/or catalysis.

• Structure (3D structures containing this domain)

• 3D Structures of SNc domains in PDB

  PDB code	Main view	Title
  1a2t		Staphylococcal nuclease, b-mercaptoethanol disulfide to v23c variant
  1a2u		Staphylococcal nuclease, v23c variant, complex with 1-n- butane thiol and 3',5'-thymidine diphosphate
  1a3t		Staphylococcal nuclease, v23c variant, complex with 2- fluoroethane thiol and 3',5'-thymidine diphosphate
  1a3u		Staphylococcal nuclease, cyclohexane thiol disulfide to v23c variant
  1a3v		Staphylococcal nuclease, cyclopentane thiol disulfide to v23c variant
  1aex		Staphylococcal nuclease, methane thiol disulfide to v23c variant
  1ena		Crystal structures of the binary ca2+ and pdtp complexes and the ternary complex of the asp 21->glu mutant of staphylococcal nuclease. implications for catalysis and ligand binding
  1enc		Crystal structures of the binary ca2+ and pdtp complexes and the ternary complex of the asp 21->glu mutant of staphylococcal nuclease. implications for catalysis and ligand binding
  1eqv		Simplification of a protein loop in staphylococcal nuclease
  1ey0		Structure of wild-type s. nuclease at 1.6 a resolution
  1ey4		Structure of s. nuclease stabilizing mutant s59a
  1ey5		Structure of s. nuclease stabilizing mutant t33v
  1ey6		Structure of s. nuclease stabilizing mutant t41i
  1ey7		Structure of s. nuclease stabilizing mutant s128a
  1ey8		Structure of s. nuclease stabilizing triple mutant p117g/h124l/s128a
  1ey9		Structure of s. nuclease stabilizing quadruple mutant t41i/p117g/h124l/s128a
  1eya		Structure of s. nuclease stabilizing quintuple mutant t33v/t41i/p117g/h124l/s128a
  1eyc		Structure of s. nuclease stabilizing quintuple mutant t41i/s59a/p117g/h124l/s128a
  1eyd		Structure of wild-type s. nuclease at 1.7 a resolution
  1ez6		Structure of s. nuclease stabilizing sextuple mutant t33v/t41i/s59a/p117g/h124l/s128a
  1ez8		Structure of s. nuclease stabilizing mutant t33v
  1f2m		Simplification of a protein loop in staphylococcal nuclease
  1f2y		Simplification of a protein loop in staphylococcal nuclease
  1f2z		Simplification of a protein loop in staphylococcal nuclease
  1ihz		Structure of s. nuclease mutant quintuple mutant v23l/v66l/i72l/i92l/v99l
  1ii3		Structure of s. nuclease quintuple mutant v23i/v66l/i72l/i92l/v99l
  1jok		Averaged structure for staphylococcal nuclease-h124l in ternary complex with ca2+ and thymidine-3',5'-bisphosphate
  1joo		Averaged structure for unligated staphylococcal nuclease- h124l
  1joq		Ensemble structures for staphylococcal nuclease-h124l in ternary complex with ca2+ and thymidine-3',5'-bisphosphate
  1jor		Ensemble structures for unligated staphylococcal nuclease- h124l
  1kaa		Stress and strain in staphylococcal nuclease
  1kab		Stress and strain in staphylococcal nuclease
  1kda		Stabilization of a strained protein loop conformation through protein engineering
  1kdb		Stabilization of a strained protein loop conformation through protein engineering
  1kdc		Stabilization of a strained protein loop conformation through protein engineering
  1nsn		The crystal structure of antibody n10-staphylococcal nuclease complex at 2.9 angstroms resolution
  1nuc		Staphylococcal nuclease, v23c variant
  1rkn		Solution structure of 1-110 fragment of staphylococcal nuclease with g88w mutation
  1snc		The crystal structure of the ternary complex of staphylococcal nuclease, ca2+, and the inhibitor pd*tp, refined at 1.65 angstroms
  1snd		Staphylococcal nuclease dimer containing a deletion of residues 114-119 complexed with calcium chloride and the competitive inhibitor deoxythymidine-3',5'-diphosphate
  1snm		Active site mutant glu-43 (right arrow) asp in staphylococcal nuclease displays nonlocal structural changes
  1sno		Protein stability in staphylococcal nuclease
  1snp		Protein stability in staphylococcal nuclease
  1snq		Protein stability in staphylococcal nuclease
  1sta		Accommodation of insertion mutations on the surface and in the interior of staphylococcal nuclease
  1stb		Accommodation of insertion mutations on the surface and in the interior of staphylococcal nuclease
  1stg		Two distinctly different metal binding modes are seen in x- ray crystal structures of staphylococcal nuclease- cobalt(ii)-nucleotide complexes
  1sth		Two distinctly different metal binding modes are seen in x- ray crystal structures of staphylococcal nuclease- cobalt(ii)-nucleotide complexes
  1stn		The crystal structure of staphylococcal nuclease refined at 1.7 angstroms resolution
  1sty		The alpha aneurism: a structural motif revealed in an insertion mutant of staphylococcal nuclease
  1syb		Transfer of a beta-turn structure to a new protein context
  1syc		Engineering alternative beta-turn types in staphylococcal nuclease
  1syd		Engineering alternative beta-turn types in staphylococcal nuclease
  1sye		Engineering alternative beta-turn types in staphylococcal nuclease
  1syf		Engineering alternative beta-turn types in staphylococcal nuclease
  1syg		Engineering alternative beta-turn types in staphylococcal nuclease
  1tqo		Cryogenic crystal structure of staphylococcal nuclease variant truncated delta+phs i92e
  1tr5		Room temperature structure of staphylococcal nuclease variant truncated delta+phs i92e
  1tt2		Cryogenic crystal structure of staphylococcal nuclease variant truncated delta+phs i92k
  1u9r		Crystal structure of staphylococcal nuclease mutant v66e/p117g/h124l/s128a at room temperature
  2enb		Crystal structures of the binary ca2+ and pdtp complexes and the ternary complex of the asp 21->glu mutant of staphylococcal nuclease. implications for catalysis and ligand binding
  2exz		Crystal structure of staphylococcal nuclease mutant t22c
  2ey1		Crystal structure of staphylococcal nuclease mutant t22v
  2ey2		Crystal structure of staphylococcal nuclease mutant t41c
  2ey5		Crystal structure of staphylococcal nuclease mutant t41s
  2ey6		Crystal structure of staphylococcal nuclease mutant t41v
  2eyf		Crystal structure of staphylococcal nuclease mutant t44v
  2eyh		Crystal structure of staphylococcal nuclease mutant t62s
  2eyj		Crystal structure of staphylococcal nuclease mutant t62v
  2eyl		Crystal structure of staphylococcal nuclease mutant t82s
  2eym		Crystal structure of staphylococcal nuclease mutant t120c
  2eyo		Crystal structure of staphylococcal nuclease mutant t120s
  2eyp		Crystal structure of staphylococcal nuclease mutant t120v
  2f0d		Crystal structure of staphylococcal nuclease mutant i92v
  2f0e		Crystal structure of staphylococcal nuclease mutant v23l
  2f0f		Crystal structure of staphylococcal nuclease mutant l25i
  2f0g		Crystal structure of staphylococcal nuclease mutant v66i
  2f0h		Crystal structure of staphylococcal nuclease mutant v66l
  2f0i		Crystal structure of staphylococcal nuclease mutant i72l
  2f0j		Crystal structure of staphylococcal nuclease mutant i72v
  2f0k		Crystal structure of staphylococcal nuclease mutant v23i/l25i
  2f0l		Crystal structure of staphylococcal nuclease mutant v23l/i72l
  2f0m		Crystal structure of staphylococcal nuclease mutant v23l/i72v
  2f0n		Crystal structure of staphylococcal nuclease mutant l25i/i72l
  2f0o		Crystal structure of staphylococcal nuclease mutant v66i/i72v
  2f0p		Crystal structure of staphylococcal nuclease mutant v66i/v99i
  2f0q		Crystal structure of staphylococcal nuclease mutant v66l/i92l
  2f0s		Crystal structure of staphylococcal nuclease mutant v66l/i92v
  2f0t		Crystal structure of staphylococcal nuclease mutant v66l/v99i
  2f0u		Crystal structure of staphylococcal nuclease mutant v23i/l25i/i72v
  2f0v		Crystal structure of staphylococcal nuclease mutant v23l/v66l/i72l
  2f0w		Crystal structure of staphylococcal nuclease mutant v23i/l25i/v66l/i72l
  2f3v		Solution structure of 1-110 fragment of staphylococcal nuclease with v66w mutation
  2f3w		Solution structure of 1-110 fragment of staphylococcal nuclease in 2m tmao
  2khs
  2nuc		Staphlococcal nuclease, ethane thiol disulfide to v23c variant
  2oeo		Cryogenic crystal structure of staphylococcal nuclease variant truncated delta+phs i92d
  2of1		Cryogenic crystal structure of the staphylococcal nuclease variant truncated delta+phs i92w
  2oxp		Crystal structure of staphylococcal nuclease mutant v66d/p117g/h124l/s128a
  2pqe		Solution structure of proline-free mutant of staphylococcal nuclease
  2pw5		Crystal structure of staphylococcal nuclease variant v66y/p117g/h124l/s128a at room temperature
  2pw7		Crystal structure of staphylococcal nuclease variant v66y/p117g/h124l/s128a at 100k
  2pyk		Crystal structure of staphylococcal nuclease variant v66q/p117g/h124l/s128a at room temperature
  2pzt		Crystal structure of staphylococcal nuclease variant v66q/p117g/h124l/s128a at 100 k
  2pzu		Crystal structure of staphylococcal nuclease variant v66n/p117g/h124l/s128a at cryogenic temperature
  2pzw		Crystal structure of staphylococcal nuclease variant v66n/p117g/h124l/s128a at room temperature
  2qdb		Crystal structure of staphylococcal nuclease variant e75q/d21n/t33v/t41i/s59a/p117g/s128a at 100 k
  2rbm
  2rdf		Crystal structure of staphyloccocal nuclease viagan/e75a variant at cryogenic temperature
  2rks		Crystal structure of staphylococcal nuclease variant phs l38k at cryogenic temperature
  2snm		In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core
  2sns		Staphylococcal nuclease. proposed mechanism of action based on structure of enzyme-thymidine 3(prime),5(prime)- biphosphate-calcium ion complex at 1.5-angstroms resolution
  2sob		Sn-ob, ob-fold sub-domain of staphylococcal nuclease, nmr, structures
  2wac
  3bdc
  3bdl
  3c1e
  3c1f
  3d4d
  3d4w
  3d6c
  3d8g
  3dhq
  3dmu
  3e5s
  3eji
  3ero
  3erq
  3evq
  3nuc		Staphlococcal nuclease, 1-n-propane thiol disulfide to v23c variant
  5nuc		Staphylococcal nuclease, 1-n-pentane thiol disulfide to v23c variant

• Links (links to other resources describing this domain)

• PFAM	SNase
  INTERPRO	IPR006021