SOCS

suppressors of cytokine signalling
SOCS
SMART accession number:SM00253
Description: suppressors of cytokine signalling
Interpro abstract (IPR001496):

The SOCS box was first identified in SH2-domain-containing proteins of the suppressor of cytokines signalling (SOCS) family [(PUBMED:9202125)] but was later also found in:

  • the WSB (WD-40-repeat-containing proteins with a SOCS box) family,
  • the SSB (SPRY domain-containing proteins with a SOCS box) family,
  • the ASB (ankyrin-repeat-containing proteins with a SOCS box) family,
  • and ras and ras-like GTPases [(PUBMED:9419338)].

The SOCS box found in these proteins is an about 50 amino acid carboxy-terminal domain composed of two blocks of well-conserved residues separated by between 2 and 10 non-conserved residues [(PUBMED:9419338)]. The C-terminal conserved region is an L/P-rich sequence of unknown function, whereas the N-terminal conserved region is a consensus BC box [(PUBMED:9869640)], which binds to the Elongin BC complex [(PUBMED:9869640), (PUBMED:10051596)]. It has been proposed that this association could couple bound proteins to the ubiquitination or proteasomal compartments [(PUBMED:10051596)].

GO process:intracellular signal transduction (GO:0035556)
Family alignment:
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There are 306 SOCS domains in 306 proteins in SMART's nrdb database.

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