SPEC

Spectrin repeats
SPEC
SMART accession number:SM00150
Description: -
Interpro abstract (IPR018159):

Spectrin repeats [(PUBMED:8266097)] are found in several proteins involved in cytoskeletal structure. These include spectrin alpha and beta subunits [(PUBMED:12672815), (PUBMED:15062087)], alpha-actinin [(PUBMED:10481917)] and dystrophin. The spectrin repeat forms a three-helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteristic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C.

Family alignment:
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There are 60411 SPEC domains in 6007 proteins in SMART's nrdb database.

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