SPRY

Domain in SPla and the RYanodine Receptor.
SPRY
SMART accession number:SM00449
Description: Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.
Interpro abstract (IPR018355): The SPRY domain is of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin [(PUBMED:9204703)]. Ca2+-release from the sarcoplasmic or endoplasmic reticulum, the intracellular Ca2+ store, is mediated by the ryanodine receptor (RyR) and/or the inositol trisphosphate receptor (IP3R).
Family alignment:
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There are 7960 SPRY domains in 6698 proteins in SMART's nrdb database.

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